Mapping interictal oscillations greater than 200 Hz recorded with intracranial macroelectrodes in human epilepsy
Mapping interictal oscillations greater than 200 Hz recorded with intracranial macroelectrodes in human epilepsy
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DOI：
10.1093/brain/awp277
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发表时间：
2010-01-01
期刊：
影响因子：
14.5
通讯作者：
Le Van Quyen, Michel
中科院分区：
文献类型：
--
作者：
Crepon, Benoit;Navarro, Vincent;Le Van Quyen, Michel
在颞叶内侧癫痫患者的发作发作区用微电极记录到发作间期超过200 Hz的高频振荡。最近的工作表明，类似的高频振荡可以检测到在癫痫发作区使用标准的诊断宏电极。然而，在这些研究中只检查了几个通道，因此关于高频振荡的空间范围的信息很少。在这里，我们提出的数据记录从大量的脑内接触空间（平均38）在16例患者的高频振荡。数据从1小时的发作间期记录采样在1024 Hz，并进行了分析，使用一种新的半自动检测程序的基础上的小波分解。通过详细的频率分析，可以迅速而可靠地将高频振荡与其他高频事件区分开来。共检测到1932个高频振荡，平均频率为261 +/- 53 Hz，振幅为11.9 +/- 6.7 mu V，持续时间为22.7 +/- 11.6 ms。来自患者的记录通常显示出几种不同的高频振荡模式。我们对11例患者进行了24种类型的分类。通常（20/24模式）高频振荡嵌套在癫痫发作中，例如尖峰或尖波，并且通常仅从一次记录接触中记录高频振荡（19/24）。出乎意料的是，在其他情况下，高频振荡（5/24）同时检测到两个或三个接触，有时相隔很远。这种大的空间范围表明，高频振荡有时可能是由厘米尺度上的神经元同步表现造成的。在颞叶内侧（9/9）或极侧（1/3）癫痫患者的致痫结构中几乎总是记录到高频振荡。他们从来没有发现在癫痫或健康的基底，侧颞或颞外新皮层，也没有在健康的杏仁核-海马复合体。这些研究结果证实，在这个尺度上，在高于200 Hz的频率下产生的振荡是内侧和极侧颞叶中的神经元生成网络的一个特定的内在属性，它们具有共同的古老系统发育起源。我们发现，这种活动可以检测到其空间范围确定与传统的颅内脑电图电极记录颞叶癫痫患者。它是癫痫发作区的可靠标志，在决定手术治疗时应予以考虑。
Interictal high-frequency oscillations over 200 Hz have been recorded with microelectrodes in the seizure onset zone of epileptic patients suffering from mesial temporal lobe epilepsy. Recent work suggests that similar high-frequency oscillations can be detected in the seizure onset zone using standard diagnostic macroelectrodes. However, only a few channels were examined in these studies, so little information is available on the spatial extent of high-frequency oscillations. Here, we present data on high-frequency oscillations recorded from a larger number of intracerebral contacts spatial (mean 38) in 16 patients. Data were obtained from 1 h of interictal recording sampled at 1024 Hz and was analysed using a new semi-automatic detection procedure based on a wavelet decomposition. A detailed frequency analysis permitted a rapid and reliable discrimination of high-frequency oscillations from other high-frequency events. A total of 1932 high-frequency oscillations were detected with an average frequency of 261 +/- 53 Hz, amplitude of 11.9 +/- 6.7 mu V and duration of 22.7 +/- 11.6 ms. Records from a patient often showed several different high-frequency oscillation patterns. We classified 24 patterns from 11 patients. Usually (20/24 patterns) high-frequency oscillations were nested in an epileptic paroxysm, such as a spike or a sharp wave, and typically high-frequency oscillations (19/24) were recorded from just one recording contact. Unexpectedly in other cases, high-frequency oscillations (5/24) were detected simultaneously on two or three contacts, sometimes separated by large distances. This large spatial extent suggests that high-frequency oscillations may sometimes result from a neuronal synchrony manifest on a scale of centimetres. High-frequency oscillations were almost always recorded in seizure-generating structures of patients suffering from mesial (9/9) or polar (1/3) temporal lobe epilepsy. They were never found in the epileptic or healthy basal, lateral temporal or extra temporal neocortex nor in the healthy amygdalo-hippocampal complex. These findings confirm that the generation of oscillations at frequencies higher that 200 Hz is, at this scale, a specific, intrinsic property of seizure-generating networks in medial and polar temporal lobes, which have a common archaic phylogenetic origin. We show that this activity can be detected and its spatial extent determined with conventional intracranial electroencephalography electrodes in records from patients with temporal lobe epilepsy. It is a reliable marker of the seizure onset zone that should be considered in decisions on surgical treatment.