THROMBOCYTOSIS OF ACTIVE RHEUMATOID DISEASE
THROMBOCYTOSIS OF ACTIVE RHEUMATOID DISEASE
复制标题
DOI：
10.1136/ard.42.5.545
复制
发表时间：
1983-01-01
影响因子：
27.4
通讯作者：
STUART, J
中科院分区：
文献类型：
--
作者：
FARR, M;SCOTT, DL;STUART, J
对类风湿性关节炎患者进行的两项横断面研究和一项纵向研究表明，血小板数量与疾病活动性的临床和实验室参数有关，包括血沉、Zeta。沉降率、血浆和血液粘度、白细胞计数、肝酶、类风湿因子和几种急性时相蛋白。血小板数量与Hb和血清白蛋白水平呈负相关。在4例活动期类风湿性关节炎患者中，111In标记的血小板存活率降低，尽管血小板计数升高，但在所研究的2例患者中，标记的血小板定位于炎症关节。血小板聚集正常。活动期类风湿性关节炎患者的血小板计数升高可能是疾病活动性的有用指标，可能代表了骨髓对血小板存活时间缩短的应激(综合征)反应，血小板隔离发生在滑膜炎症区域。
Two cross-sectional and 1 longitudinal study of patients with rheumatoid arthritis showed that platelet number correlated with both clinical and laboratory parameters of disease activity, including erythrocyte sedimentation rate, .zeta. sedimentation ratio, viscosity of plasma and blood, white cell count, liver enzymes, rheumatoid factor and several acute-phase proteins. There was also an inverse relationship between platelet number and the Hb and serum albumin levels. 111In-labelled platelet survival was reduced in 4 patients with active rheumatoid arthritis despite a raised platelet count, with labeled platelets being localized to inflamed joints in the 2 patients studied. Platelet aggregation was normal. The raised platelet count of active rheumatoid arthritis may be a useful index of disease activity and may represent a bone marrow stress (syndrome) response to shortened platelet survival, with platelet sequestration occurring in areas of synovial inflammation.