New Understanding on the Role of Proteinuria in Progression of Chronic Kidney Disease
New Understanding on the Role of Proteinuria in Progression of Chronic Kidney Disease
复制标题
蛋白尿在慢性肾脏病进展中作用的新认识
DOI：
10.1007/978-981-13-8871-2_24
复制
发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Lv, Lin-Li
中科院分区：
文献类型：
--
作者：
Liu, Dan;Lv, Lin-Li
蛋白尿被认为是慢性肾脏疾病进展的重要标志和危险因素。然而，在慢性肾脏疾病进展中的确切作用机制尚不清楚。来自特定过滤化合物的系膜毒性，如白蛋白结合脂肪酸和转铁蛋白/铁，小管超载和增生，以及促炎分子如MCP-1和炎症细胞因子的诱导是一些被提出的机制。通过限制蛋白质或抗高血压治疗来逆转肾小球内高血压可能通过减少肾小球血流动力学损伤和减少蛋白质滤过而有益。因此，了解蛋白尿及其在肾小管间质炎症和纤维化中的作用，对于研究抗蛋白尿等肾保护治疗，延缓慢性肾病的进展具有重要意义。
Proteinuria is identified as an important marker and risk factor of progression in chronic kidney disease. However, the precise mechanism of action in the progress of chronic kidney disease is still unclear. Mesangial toxicity from specific filtered compounds such as albumin-bound fatty acids and transferrin/iron, tubular overload and hyperplasia, and induction of proinflammatory molecules such as MCP-1 and inflammatory cytokines are some of the proposed mechanisms. Reversing intraglomerular hypertension with protein restriction or antihypertensive therapy may be beneficial both by diminishing hemodynamic injury to the glomeruli and by reducing protein filtration. Therefore, understanding proteinuria and its role in renal tubular interstitial inflammation and fibrosis is of great significance for the study of renal protective therapy, such as antiproteinuric treatments, and delaying the progression of chronic renal disease.