GROUP SEQUENTIAL-PROCEDURES - CALENDAR VERSUS INFORMATION TIME
GROUP SEQUENTIAL-PROCEDURES - CALENDAR VERSUS INFORMATION TIME
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DOI：
10.1002/sim.4780081003
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发表时间：
1989-10-01
影响因子：
2
通讯作者：
DEMETS, DL
中科院分区：
文献类型：
--
作者：
LAN, KKG;DEMETS, DL
本文描述了在使用成组序贯程序监测临床试验中期分析时信息时间和日历时间之间的关系。信息时间是已观察到的最大受试者或事件的比例。中期分析通常发生在特定的日历时间，而经典的成组序贯程序的定义发生在信息时间方面。我们扩展了Lan和DeMets 1的一般组序贯方法，使其也包含这种情况。
This paper describes the relationship between information time and calendar time in the use of group sequential procedures to monitor interim analyses of clinical trials. Information time is the proportion of maximum subjects or events already observed. Interim analyses often occur at specified calendar times while the definition of classic group sequential procedures occurs in terms of information time. We extend the general group sequential approach of Lan and DeMets1 to include this situation as well.