Treatment of acute idiopathic thrombocytopenia of childhood with intravenous infusions of gammaglobulin.
Treatment of acute idiopathic thrombocytopenia of childhood with intravenous infusions of gammaglobulin.
复制标题
静脉输注丙种球蛋白治疗儿童急性特发性血小板减少症。
DOI：
10.1016/s0022-3476(85)80231-6
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
M. Hilgartner
中科院分区：
文献类型：
--
作者：
J. Bussel;J. Bussel;Alice Goldman;Alice Goldman;P. Imbach;P. Imbach;I. Schulman;I. Schulman;M. Hilgartner;M. Hilgartner
29例急性特发性血小板减少性紫癜患者静脉注射丙种球蛋白1 mg/kg/d，其中15例未经治疗，10例对类固醇耐药，4例依赖类固醇。24小时内平均血小板增加> 50，000/μl;平均峰值血小板计数为194，000/μl。25例患者中有18例仅需要一次输注;这18例患者中有10例从未需要任何额外（维持）治疗。既往未经治疗和类固醇耐药患者的结局相同;然而，既往未经治疗的患者仅需要1.8 gm/kg总剂量的丙种球蛋白，而类固醇耐药患者接受3.9 gm/kg。29名患者中只有一名激素依赖儿童仍需要维持治疗，间隔6周。毒性很小。通过不收治病人和在一次而不是五次就诊中进行治疗，成本被降到了最低。
Gammaglobulin treatment was given at a dose of 1 mg/kg/day intravenously in 29 patients with acute idiopathic thrombocytopenic purpura: 15 previously untreated, 10 resistant to steroids, and four who were steroid dependent. The average platelet increase in 24 hours was >50,000/μl; the average peak platelet count was 194,000/μl. Eighteen of 25 patients required only one infusion; 10 of these 18 never required any additional (maintenance) therapy. Outcome in previously untreated and steroid-resistant patients was identical; however, previously untreated patients required only 1.8 gm/kg total dose of gammaglobulin, whereas steroid-resistant patients received 3.9 gm/kg. Only one steroid-dependent child of the 29 patients still requires maintenance therapy, at 6-week intervals. Toxicity was minimal. Cost was minimized by not admitting patients and by giving treatment in one visit, rather than five.