Three-dimensional Čerenkov tomography of energy deposition from ionizing radiation beams.
Three-dimensional Čerenkov tomography of energy deposition from ionizing radiation beams.
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DOI：
10.1364/ol.38.000634
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发表时间：
2013-03-01
期刊：
影响因子：
3.6
通讯作者：
Pogue BW
中科院分区：
文献类型：
--
作者：
Glaser AK;Voigt WH;Davis SC;Zhang R;Gladstone DJ;Pogue BW
自1930年S发现以来，ČErenkov效应(带电粒子在介质中的光发射速度快于介质中的局部光速)在高能物理研究的发展中一直是至关重要的。发射的光能够描述带电粒子的轨迹、能量、速度和质量，这使得科学家能够研究亚原子粒子，探测中微子，并探索星际物质的性质。然而，到目前为止，这一过程的所有应用都集中在识别粒子本身，而不是它们对周围环境的影响。在这里，我们探索了ČErenkov效应在恢复介质中电离辐射能量沉积的空间分布方面的新应用，并将其应用于医学物理中的剂量确定问题。通过捕获医用直线加速器(LINAC)X射线束诱导的ČErenkov光的多幅投影图像，我们首次展示了成功的三维(3D)层析重建所给予的剂量分布。
Since its discovery during the 1930’s, the Čerenkov effect (light emission from charged particles traveling faster than the local speed of light in a dielectric medium) has been paramount in the development of high-energy physics research. The ability of the emitted light to describe a charged particle’s trajectory, energy, velocity, and mass has allowed scientists to study subatomic particles, detect neutrinos, and explore the properties of interstellar matter. However, all applications of the process to date have focused on identification of particle’s themselves, rather than their effect upon the surroundings through which they travel. Here, we explore a novel application of the Čerenkov effect for the recovery of the spatial distribution of ionizing radiation energy deposition in a medium, and apply it to the issue of dose determination in medical physics. By capturing multiple projection images of the Čerenkov light induced by a medical linear accelerator (LINAC) x-ray photon beam, we demonstrate the successful three-dimensional (3D) tomographic reconstruction of the imparted dose distribution for the first time.