Future planning: default network activity couples with frontoparietal control network and reward-processing regions during process and outcome simulations
Future planning: default network activity couples with frontoparietal control network and reward-processing regions during process and outcome simulations
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DOI：
10.1093/scan/nsu001
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发表时间：
2014-12-01
影响因子：
4.2
通讯作者：
Schacter, Daniel L.
中科院分区：
文献类型：
--
作者：
Gerlach, Kathy D.;Spreng, R. Nathan;Schacter, Daniel L.
我们每天花很多时间想象如何实现未来的目标，以及当我们实现这些目标时会发生什么。尽管这种目标导向的模拟很普遍，但关于计划的神经影像学研究主要集中在额叶的执行过程。这个实验检查了过程模拟的神经基础，在此期间，参与者想象自己通过实现目标的步骤，以及结果模拟，在此期间，参与者想象与实现目标相关的事件。在扫描仪中，参与者参与了这些模拟任务和一个奇数/偶数控制任务。我们假设，过程模拟会招募默认和额顶叶控制网络区域，而结果模拟，使我们能够预期实现目标的情感后果，将招募默认和奖励处理区域。我们对与过程和结果模拟共变的大脑活动的分析证实了这些假设。后扣带回，背外侧前额叶皮层和前下顶叶小叶种子的功能连接分析表明，他们的活动是相关的过程模拟和与分布式网络的默认和额顶叶控制网络区域。在结果模拟，内侧前额叶皮层和杏仁核种子共同变化在一起，形成了一个功能网络与默认和奖励处理区域。
We spend much of our daily lives imagining how we can reach future goals and what will happen when we attain them. Despite the prevalence of such goal-directed simulations, neuroimaging studies on planning have mainly focused on executive processes in the frontal lobe. This experiment examined the neural basis of process simulations, during which participants imagined themselves going through steps toward attaining a goal, and outcome simulations, during which participants imagined events they associated with achieving a goal. In the scanner, participants engaged in these simulation tasks and an odd/even control task. We hypothesized that process simulations would recruit default and frontoparietal control network regions, and that outcome simulations, which allow us to anticipate the affective consequences of achieving goals, would recruit default and reward-processing regions. Our analysis of brain activity that covaried with process and outcome simulations confirmed these hypotheses. A functional connectivity analysis with posterior cingulate, dorsolateral prefrontal cortex and anterior inferior parietal lobule seeds showed that their activity was correlated during process simulations and associated with a distributed network of default and frontoparietal control network regions. During outcome simulations, medial prefrontal cortex and amygdala seeds covaried together and formed a functional network with default and reward-processing regions.