Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity
Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity
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DOI：
10.1007/s00213-005-0104-6
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发表时间：
2005-11-01
影响因子：
3.4
通讯作者：
Robbins, TW
中科院分区：
文献类型：
--
作者：
Clark, L;Roiser, JP;Robbins, TW
基本原理：减少5-羟色胺神经传递是牵连的冲动控制障碍，但在健康人类subjects.Objectives的抑制过程中的5-羟色胺的参与仍不清楚：调查急性操纵的5-羟色胺和基因型在一个功能多态性的5-羟色胺转运体（5-HTT）的基因编码的反应抑制的既定措施的影响。在42名健康受试者中，采用双盲交叉设计，通过急性色氨酸耗竭（ATD）程序降低血清素功能。停止信号任务（SST）在饮料施用后57小时施用。5-HTT多态性，性别和特质impulsivity.Results的影响：ATD与血浆色氨酸水平显着耗尽，但没有增加停止信号反应时间相比，平衡（安慰剂）氨基酸混合物。在安慰剂条件下，5-HTT多态性的短等位基因受试者在SST上并不比长等位基因纯合子受试者更冲动，并且对ATD的影响也不成比例地敏感。有没有影响的性别或特质冲动ATD诱导的changes.Conclusions：我们发现没有支持参与大脑5-羟色胺神经传递在这种形式的抑制控制在健康的人类受试者。
Rationale: Reduced serotonin neurotransmission is implicated in disorders of impulse control, but the involvement of serotonin in inhibitory processes in healthy human subjects remains unclear.Objectives: To investigate the effects of an acute manipulation of serotonin and genotype at a functional polymorphism in a gene coding for the serotonin transporter (5-HTT) on an established measure of response inhibition.Methods: Serotonin function was reduced by the acute tryptophan depletion (ATD) procedure in a double-blind, crossover design in 42 healthy subjects. The Stop Signal Task (SST) was administered 57 h after drink administration. The influences of 5-HTT polymorphism, gender and trait impulsivity were investigated.Results: ATD was associated with significant depletion of plasma tryptophan levels but did not increase the stop signal reaction time in comparison to the balanced (placebo) amino acid mixture. Subjects possessing the short allele of the 5-HTT polymorphism were not more impulsive on the SST than subjects homozygous for the long allele under placebo conditions and were not disproportionately sensitive to the effects of ATD. There was no effect of gender or trait impulsivity on ATD-induced change.Conclusions: We find no support for the involvement of brain serotonin neurotransmission in this form of inhibitory control in healthy human subjects.