Global, Low-Amplitude Cortical State Predicts Response Outcomes in a Selective Detection Task in Mice.
Global, Low-Amplitude Cortical State Predicts Response Outcomes in a Selective Detection Task in Mice.
复制标题
全局低幅度皮质状态预测小鼠选择性检测任务中的响应结果。
DOI：
10.1093/cercor/bhab339
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Zagha,Edward
中科院分区：
文献类型：
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作者：
Marrero,Krista;Aruljothi,Krithiga;Zareian,Behzad;Gao,Chengchun;Zhang,Zhaoran;Zagha,Edward
自发神经元活动强烈影响刺激编码和行为反应。我们试图确定新皮层刺激前活动对刺激检测的影响。我们在一个选择性的胡须检测任务中训练小鼠，在这个任务中，它们学会了对一个胡须场中的目标刺激做出反应（舔），而忽略对侧胡须场中的干扰刺激。在专家任务的性能，我们使用宽场钙离子成像，以评估刺激前和刺激后的神经元活动广泛的额叶和顶叶皮层。我们发现，较低的前刺激活动与增强的刺激检测相关：较低的前刺激活动预测响应与无响应结果和更快的反应时间。预测试验结果的活动分布在背侧新皮层，而不是局限于胡须或舔区域。使用主成分分析，我们表明，反应试验与一个独特的和变量较少的刺激前神经元子空间。对于单个单位，刺激前选择概率较弱，但分布较广，低于机会选择概率与较强的感觉和运动编码相关。这些研究结果支持低振幅和低变异性作为刺激检测的最佳prestimulus皮层状态，呈现全球性，并预测目标和干扰刺激的反应结果。
Spontaneous neuronal activity strongly impacts stimulus encoding and behavioral responses. We sought to determine the effects of neocortical prestimulus activity on stimulus detection. We trained mice in a selective whisker detection task, in which they learned to respond (lick) to target stimuli in one whisker field and ignore distractor stimuli in the contralateral whisker field. During expert task performance, we used widefield Ca2+imaging to assess prestimulus and post-stimulus neuronal activity broadly across frontal and parietal cortices. We found that lower prestimulus activity correlated with enhanced stimulus detection: lower prestimulus activity predicted response versus no response outcomes and faster reaction times. The activity predictive of trial outcome was distributed through dorsal neocortex, rather than being restricted to whisker or licking regions. Using principal component analysis, we demonstrate that response trials are associated with a distinct and less variable prestimulus neuronal subspace. For single units, prestimulus choice probability was weak yet distributed broadly, with lower than chance choice probability correlating with stronger sensory and motor encoding. These findings support low amplitude and low variability as an optimal prestimulus cortical state for stimulus detection that presents globally and predicts response outcomes for both target and distractor stimuli.