Association between the TP53 codon72 polymorphism and oral cancer risk and prognosis
Association between the TP53 codon72 polymorphism and oral cancer risk and prognosis
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DOI：
10.1016/j.oraloncology.2006.12.001
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发表时间：
2007-11-01
期刊：
影响因子：
4.8
通讯作者：
Katoh, Takahiko
中科院分区：
文献类型：
--
作者：
Kuroda, Yoshiki;Nakao, Hiroyuki;Katoh, Takahiko
TP 53密码子72多态性最近已被广泛研究，以确定致癌的危险因素。然而，关于TP 53 codon 72多态性与口腔癌发病风险及治疗后预后的关系的报道较少。我们评估了100例口腔癌病例和271例非癌对照中TP 53密码子72多态性的基因型分布。TP 53密码子72多态性的Arg/Arg、Arg/Pro、Pro/Pro三种基因型在口腔癌组和对照组中的频率差异无统计学意义。然而，按吸烟状况分层，我们发现，Pro/Pro基因型的非吸烟者的调整优势比显著增加（调整OR = 2.70，95%置信区间= 1.07-6.82）。我们还发现，与Arg/Pro基因型相比，Pro/Pro基因型的病例往往具有较短的治疗后生存期（p = 0.06）。我们的研究结果表明TP 53密码子72多态性的Pro/Pro基因型增加非吸烟者口腔癌的风险并影响其预后。(C)2006爱思唯尔有限公司保留所有权利。
The TP53 codon72 polymorphism has recently been extensively studied to determine the risk factor for carcinogenesis. However, there are few reports about the relationship between the TP53 codon72 polymorphism and oral cancer risk or post treatment prognosis. We evaluated the genotypic distribution of the TP53 codon72 polymorphism in 100 oral cancer cases and 271 non-cancer controls. There were no significant differences in the frequencies of the three genotypes (Arg/Arg, Arg/Pro, Pro/Pro) of the TP53 codon72 polymorphism between oral cancer cases and controls. However, stratifying by smoking status, we found that the adjusted odds ratio for non-smokers with the Pro/Pro genotype was significantly increased (adjusted OR = 2.70, 95% confidence interval = 1.07-6.82). We also found that the cases with the Pro/Pro genotype tended to have a shorter post-treatment survival compared with those with the Arg/Pro genotype (p = 0.06). Our results suggest the Pro/Pro genotype of the TP53 codon72 polymorphism increases oral cancer risk in non-smokers and worsens their prognosis. (C) 2006 Elsevier Ltd. All rights reserved.