Association of the ABCA1 gene polymorphisms with type 2 DM in a Japanese population
Association of the ABCA1 gene polymorphisms with type 2 DM in a Japanese population
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DOI：
10.1016/j.bbrc.2005.01.119
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发表时间：
2005-04-01
影响因子：
3.1
通讯作者：
Kato, T
中科院分区：
文献类型：
--
作者：
Daimon, M;Kido, T;Kato, T
为了检查ATP结合盒转运蛋白1（ABCA1）基因与2型糖尿病（DM）的关联，我们研究了ABCA1基因的遗传多态性，包括其链接不平衡（LD）和使用日本人群的单倍型分析。将样品集（DM：72，IGT：75和NGT：227）与从启动子区域分布到ABCA1基因的最后一个外显子的34个SNP进行基因分型。以成对的方式评估SNP之间的LD。在构建的13个LD块中，在5'-Region的LD块中显示出研究组之间的单倍型分布有显着差异（NGT与IGT + DM：总体P = 0.0180； NGT与DM：0.0001）。费舍尔的确切概率测试（NGT与DM）显示LD块的单倍型2（p = 0.0001）的显着关联，优势比（OR）为2.53（94％CI：1.62-4.12）。外交型分析还显示，外交型与单倍型2（OR：2.59，95％CI：1.48-4.54，p = 0.0013）。 （c）2005 Elsevier Inc.保留所有权利。
To examine the association of the ATP-binding cassette transporter 1 (ABCA1) gene with type 2 diabetes (DM), we studied genetic polymorphisms of the ABCA1 gene including its linkage disequilibrium (LD) and haplotype analyses using a Japanese population. A sample set (DM:72, IGT:75, and NGT:227) was genotyped with 34 SNPs distributed from the promoter region to the last exon of the ABCA1 gene. LD between SNPs was assessed in pairwise manner. Among 13 LD blocks constructed, an LD block at the 5'-region showed a significant difference in the haplotype distribution between the study groups (NGT vs. IGT + DM: overall p = 0.0180; NGT vs. DM:0.0001). Fisher's exact probability test (NGT vs. DM) showed a significant association of the haplotype 2 of the LD block (p = 0.0001), with an odds ratio (OR) of 2.53 (94%CI:1.62-4.12). Diplotype analysis also showed a significant association of the diplotypes with the haplotype 2 (OR:2.59, 95%CI:1.48-4.54, p = 0.0013). (C) 2005 Elsevier Inc. All rights reserved.