Polarized Exocytosis.
Polarized Exocytosis.
复制标题
DOI：
10.1101/cshperspect.a027870
复制
发表时间：
2017
影响因子：
7.2
通讯作者：
Jingwen Zeng;S. Feng;Bin Wu;Wei Guo
中科院分区：
文献类型：
--
作者：
Jingwen Zeng;S. Feng;Bin Wu;Wei Guo
极化胞吐作用通常被认为是多步骤的囊泡运输过程，其中膜结合的载体从高尔基体或内体区室运输到质膜的特定位点。细胞中的极化胞吐作用通过由信号分子如Rho家族的小GTP酶编排的膜运输机制和细胞骨架的协调作用来实现。阐明极化胞吐的分子机制对于我们理解从神经元发育到肿瘤侵袭的广泛病理生理过程至关重要。
Polarized exocytosis is generally considered as the multistep vesicular trafficking process in which membrane-bounded carriers are transported from the Golgi or endosomal compartments to specific sites of the plasma membrane. Polarized exocytosis in cells is achieved through the coordinated actions of membrane trafficking machinery and cytoskeleton orchestrated by signaling molecules such as the Rho family of small GTPases. Elucidating the molecular mechanisms of polarized exocytosis is essential to our understanding of a wide range of pathophysiological processes from neuronal development to tumor invasion.