Five different glucose-6-phophate dehydrogenase (G6PD) variants found among 11 G6PD-deficient persons in Flores Island, Indonesia
Five different glucose-6-phophate dehydrogenase (G6PD) variants found among 11 G6PD-deficient persons in Flores Island, Indonesia
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DOI：
10.1007/s10038-003-0073-8
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发表时间：
2003-10-01
影响因子：
3.5
通讯作者：
Kawamoto, F
中科院分区：
文献类型：
--
作者：
Matsuoka, H;Arai, M;Kawamoto, F
我们对弗洛勒斯岛的四所小学进行了疟疾诊断和治疗调查。弗洛勒斯岛是印度尼西亚群岛之一，面积 17,000 平方公里(2)，人口 180 万。在接受检查的人中，24.4％被诊断患有疟疾（90/363）并立即服用药物。同时进行了葡萄糖-6-磷酸脱氢酶（G6PD）测试，16人（4.4%）被诊断为G6PD缺乏症。 11 人同意对 G6PD 基因组进行分析。我们对这些受试者进行了分析，发现 1 例 G6PD Vanua Lava (383T>C)、5 例 G6PD Coimbra (592C>T)、1 例 G6PD Viangchan (871G>A)、1 例 G6PD Chatham (1003G>A) 和 3 例 G6PD Kaiping (1388G>A)。这些是意想不到的发现，因为在如此小的人群中发现了五种不同的 G6PD 变体。这表明弗洛勒斯岛的人们来自不同的血统。
We conducted a survey for malaria diagnosis and treatment in four primary schools in Flores Island, one of the Indonesian Islands with an area of 17,000 km(2) and a population of 1.8 million. Of those examined, 24.4% were diagnosed as having malaria (90/363) and administered medicine immediately. A glucose-6-phophate dehydrogenase (G6PD) test was performed at the same time, and 16 persons (4.4%) were diagnosed as G6PD deficient. Eleven persons consented to analysis of the G6PD genome. We analyzed these subjects and found one case of G6PD Vanua Lava (383T>C), five cases of G6PD Coimbra (592C>T), one case of G6PD Viangchan (871G>A), one case of G6PD Chatham (1003G>A), and three cases of G6PD Kaiping (1388G>A). These were unexpected findings because five different G6PD variants were found in such a small population. This suggests that people of Flores Island are derived from various ancestries.