Impact of Fetal-Neonatal Iron Deficiency on Recognition Memory at 2 Months of Age.
Impact of Fetal-Neonatal Iron Deficiency on Recognition Memory at 2 Months of Age.
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DOI：
10.1016/j.jpeds.2015.08.035
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发表时间：
2015-12
期刊：
影响因子：
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通讯作者：
Lozoff B
中科院分区：
文献类型：
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作者：
Geng F;Mai X;Zhan J;Xu L;Zhao Z;Georgieff M;Shao J;Lozoff B
探讨胎儿-新生儿缺铁对婴儿早期再认记忆的影响。在动物模型中，围产期铁缺乏会延迟或破坏海马的发育，因此可能会损害人类婴儿的相关神经功能，如识别记忆。采用事件相关电位对出生时缺铁和缺铁的2个月婴儿进行听觉再认记忆任务的比较。胎儿-新生儿缺铁有两种定义：高锌原卟啉/血红素比值（ZPP/H > 118 μmol/mol）或低血清铁蛋白（< 75 μg/l）。晚慢波（LSW）被用来测量婴儿识别母亲的声音。胎儿-新生儿铁缺乏的ERP模式差异显着，定义为高脐带ZPP/H，而不是低铁蛋白。比较35例铁缺乏（ZPP/H > 118 μmol/mol）和92例低ZPP/H（铁充足）的婴儿，只有铁充足的婴儿在额中央和顶枕区对陌生人声音的LSW幅值大于母亲声音，表明对母亲声音的识别。铁充足的婴儿表现出识别母亲声音的电生理证据，而胎儿-新生儿铁缺乏的婴儿则没有。他们在两个月大时较差的听觉识别记忆与胎儿-新生儿缺铁对发育中的海马体的影响一致。
To assess the effects of fetal-neonatal iron deficiency on recognition memory in early infancy. Perinatal iron deficiency delays or disrupts hippocampal development in animal models and thus may impair related neural functions in human infants, such as recognition memory. Event-related potentials were used in an auditory recognition memory task to compare 2-month-old Chinese infants with iron sufficiency or deficiency at birth. Fetal- neonatal iron deficiency was defined two ways: high zinc protoporphyrin/heme ratio (ZPP/H > 118 μmol/mol) or low serum ferritin (< 75 μg/l) in cord blood. Late slow wave (LSW) was used to measure infant recognition of mother’s voice. ERP patterns differed significantly for fetal-neonatal iron deficiency as defined by high cord ZPP/H but not low ferritin. Comparing 35 infants with iron deficiency (ZPP/H > 118 μmol/mol) to 92 with lower ZPP/H (iron-sufficient), only infants with iron sufficiency showed larger LSW amplitude for stranger’s voice than mother’s voice in frontal-central and parietal-occipital locations, indicating the recognition of mother’s voice. Infants with iron sufficiency showed electrophysiological evidence of recognizing their mother’s voice, whereas infants with fetal-neonatal iron deficiency did not. Their poorer auditory recognition memory at two months of age is consistent with effects of fetal-neonatal iron deficiency on the developing hippocampus.