Design and fabrication of well confined uniform magnetic field exposure systems.
Design and fabrication of well confined uniform magnetic field exposure systems.
复制标题
DOI：
10.1002/bem.2250150610
复制
发表时间：
1994
影响因子：
1.9
通讯作者：
B. Wilson;K. Caputa;M. Stuchly;J. D. Saffer;K. Davis;Calvin E. Washam;Lloyd G. Washam;Glenn R. Washa
中科院分区：
文献类型：
--
作者：
B. Wilson;K. Caputa;M. Stuchly;J. D. Saffer;K. Davis;Calvin E. Washam;Lloyd G. Washam;Glenn R. Washa
需要提供良好的磁场均匀性、最小的杂散场、最小的发热、振动和嗡嗡声以及电流在线圈中流动的真实假暴露能力的暴露系统来严格确定弱磁场的生物效应。基于丙烯酸聚合物线圈支撑结构和双绞线双线线圈绕组的设计被用来制造几种不同的系统，用于将实验室动物和细胞培养物暴露于磁场。这些系统在假曝光模式下的曝光场均匀性、杂散场抑制和曝光场消除方面表现出优异的性能特征。一个自定义编写的计算机程序被用来确定最佳的安排线圈方面的磁场均匀性的曝光量和杂散场遏制。对于体内暴露，模块由四个Merritt四线圈组组成，内置于单个结构中，并定位以形成八极，磁场指向水平面。对于体外应用，选择两种不同的线圈配置来产生所需的垂直场。一个四极系统，包括模块组成的两个梅里特四线圈组并排排列，以限制杂散磁场，作为原型。在第二种配置中，一个梅里特四线圈组被定位在另一个内部以形成同心线圈组。在两种体外系统中，暴露室连接到远程商业培养箱，以减少暴露体积中的环境磁场。（250字处删节）
Exposure systems that provide good magnetic field uniformity, minimum stray fields, and minimal heating, vibration, and hum, as well as capability for true sham exposure in which current flows in the coils, are needed to determine rigorously the biological effects of weak magnetic fields. Designs based on acrylic polymer coil support structures and twisted pair bifilary coil windings were employed to fabricate several different systems for the exposure of laboratory animals and cell cultures to magnetic fields. These systems exhibit excellent performance characteristics in terms of exposure field uniformity, stray field containment, and exposure field cancellation in the sham exposure mode. A custom-written computer program was used to determine the best arrangement for coils with regard to field uniformity in the exposure volume and stray field containment. For in vivo exposures, modules were made up of four Merritt four-coil sets, built into a single structure and positioned to form an octapole with fields directed in the horizontal plane. For in vitro applications, two different coil configurations were selected to produce the vertical fields required. A quadrupole system, comprising modules consisting of two Merritt four-coil sets arranged side by side to limit stray fields, was built as a prototype. In the second configuration, one Merritt four-coil set was positioned inside the other to form a concentric coil set. In both in vitro systems, exposure chambers were connected to remote commercial incubators in order to reduce ambient magnetic fields in the exposure volume.(ABSTRACT TRUNCATED AT 250 WORDS)