[Pathogenic factors of mycoplasma].
[Pathogenic factors of mycoplasma].
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DOI：
10.3412/jsb.70.369
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发表时间：
2015-01-01
期刊：
影响因子：
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通讯作者：
Shimizu, Takashi
中科院分区：
文献类型：
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作者：
Shimizu, Takashi
支原体是能够自我复制的最小的生物体，并在人类中引起各种疾病。尤其是，已知肺炎支原体（Mycoplasma pneumoniae）是肺炎的病原体。2010 - 2012年，M.肺炎感染在世界范围内被报道（例如，在法国、以色列和日本）。在支原体引起的疾病中，支原体诱导的强烈炎症反应被认为是重要的。然而，支原体缺乏细胞壁，并且不具有炎症诱导内毒素如脂多糖（LPS）。我们从致病性支原体中纯化了炎症诱导因子，并鉴定它们是脂蛋白。来自支原体的脂蛋白通过Toll样受体（TLR）2诱导炎症反应。此外，我们还证明了M. pneumoniae在诱导炎症反应中起重要作用。M.肺炎克雷伯菌通过TLR 2非依赖性途径诱导炎症反应。TLR 4、炎性小体和自噬参与了这种TLR 2独立的炎症反应诱导。
Mycoplasmas are smallest organisms capable of self-replication and cause various diseases in human. Especially, Mycoplasma pneumoniae is known as an etiological agent of pneumonia. From 2010 to 2012, epidemics of M. pneumoniae infections were reported worldwide (e.g., in France, Israel, and Japan). In the diseases caused by mycoplasmas, strong inflammatory responses induced by mycoplasmas have been thought to be important. However, mycoplasmas lack of cell wall and do not possess inflammation-inducing endotoxin such as lipopolysaccharide (LPS). We purified inflammation-inducing factors from pathogenic mycoplasmas and identified that they were lipoproteins. Lipoproteins derived from mycoplasmas induced inflammatory responses through Toll-like receptor (TLR) 2. In addition, we demonstrated that cytadherent property of M. pneumoniae played an important role in induction of inflammatory responses. Cytadherent property of M. pneumoniae induced inflammatory responses through TLR2 independent pathway. TLR4, inflammasomes, and autophagy were involved in this TLR2 independent induction of inflammatory responses.