Quantification of cerebral arterial blood volume using arterial spin labeling with intravoxel incoherent motion-sensitive gradients
Quantification of cerebral arterial blood volume using arterial spin labeling with intravoxel incoherent motion-sensitive gradients
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DOI：
10.1002/mrm.20867
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发表时间：
2006-05-01
影响因子：
3.3
通讯作者：
Kim, SG
中科院分区：
文献类型：
--
作者：
Kim, T;Kim, SG
脑动脉血容量（CBVa）的定量对于理解血管调节是重要的。为了能够测量CBVa与扩散加权（DW）动脉自旋标记（ASL），一个理论框架，使用体素内不相干运动（IVIM）的影响。通过改变标记后延迟（w）和磁化传递率（MTR），在异氟烷麻醉下，在9.4 T下，在大鼠脑DW-ASL中评价IVIM模型中的伪扩散系数（D-*）。在w >= 0.3 s时，D* 及其体积分数降低，而归一化表观扩散系数（ADC）随MTR的增加而增加，表明D* 与CBVa密切相关。因此，具有和不具有DW梯度的ASL测量之间的差异与CBVa相关。将通过这种方法测量的CBVa值与使用ASL的组织和血管（MOTIVE）技术的调制获得的值进行比较，ASL改变MT水平而不改变自旋标记效率。两种方法的CBVa值高度相关。测量的CBVa。在25-50 mmHg的PaCO 2范围内，数值与脑血流量（CBF）呈线性相关; δ CBVa（ml/100 g）= 0.007（min（-1））× δ CBF（ml/100 g/min）。DW-ASL方法简单且易于实施用于人类和动物CBVa研究。
Quantification of cerebral arterial blood volume (CBVa) is important for understanding vascular regulation. To enable measurement of CBVa with diffusion-weighted (DW) arterial spin labeling (ASL), a theoretical framework was developed using the effects of intravoxel incoherent motion (IVIM). The pseudo-diffusion coefficient (D-*) in the IVIM model was evaluated at 9.4 T in DW-ASL of rat brain under isoflurane anesthesia by variations of both post-labeling delay (w) and magnetization transfer ratio (MTR). D* and its volume fraction decreased at values of w >= 0.3 s, and the normalized apparent diffusion coefficient (ADC) increased with MTR, suggesting that D* is closely correlated with CBVa. Thus, the difference between ASL measurements with and without DW gradients is related to CBVa. The CBVa values measured by this approach were compared with values obtained using the modulation of tissue and vessel (MOTIVE) technique with ASL, which varies MT levels without changing spin labeling efficiency. CBVa values from both methods were highly correlated. The measured CBVa. values were linearly correlated with cerebral blood flow (CBF) for a PaCO2 range of 25-50 mmHg; Delta CBVa (ml/100 g) = 0.007 (min(-1)) x Delta CBF (ml/100 g/min). The DW-ASL approach is simple and easy to implement for human and animal CBVa studies.