Chronic post-traumatic stress disorder-related traits in a rat model of low-level blast exposure.
Chronic post-traumatic stress disorder-related traits in a rat model of low-level blast exposure.
复制标题
低水平爆炸暴露大鼠模型中的慢性创伤后应激障碍相关特征。
DOI：
10.1016/j.bbr.2016.09.061
复制
发表时间：
2018
影响因子：
2.7
通讯作者：
Elder,GregoryA
中科院分区：
文献类型：
--
作者：
Perez-Garcia,Georgina;GamaSosa,MiguelA;DeGasperi,Rita;Lashof-Sullivan,Margaret;Maudlin-Jeronimo,Eric;Stone,JamesR;Haghighi,Fatemeh;Ahlers,StephenT;Elder,GregoryA
轻度创伤性脑损伤（mTBI）后的脑震荡综合征被认为是一种良性综合征，通常在受伤后的几个月内消退。然而，在一些个体中，症状变得慢性和持续。这是在最近从伊拉克和阿富汗冲突中返回的退伍军人中看到的大多数与爆炸有关的mTBI的一个显著特征。在这些退伍军人中，具有脑震荡后综合征和创伤后应激障碍特征的慢性综合征一直很突出。在过去的十年中，爆炸相关的TBI的动物模型发展迅速，导致爆炸病理生理学的理解的进步。然而，大多数研究都集中在爆炸对神经系统的急性至亚急性影响，并且通常研究了能量更接近人类中度至重度TBI的更高强度爆炸暴露。很少有动物研究涉及较低水平冲击波暴露的慢性效应，这些效应与人类mTBI或亚临床冲击波暴露的慢性效应更相似。在这里，我们描述了一个大鼠模型的重复低水平爆炸暴露，诱导各种焦虑和PTSD相关的行为特征，包括夸大的恐惧反应，当动物在最后一次爆炸暴露后28至35周之间进行测试时。这些动物提供了一个模型，以研究慢性和持续的行为影响的冲击波，包括创伤后应激障碍的关系，以mTBI的双重诊断退伍军人。
The postconcussion syndrome following mild traumatic brain injuries (mTBI) has been regarded as a mostly benign syndrome that typically resolves in the immediate months following injury. However, in some individuals, symptoms become chronic and persistent. This has been a striking feature of the mostly blast-related mTBIs that have been seen in veterans returning from the recent conflicts in Iraq and Afghanistan. In these veterans a chronic syndrome with features of both the postconcussion syndrome and post-traumatic stress disorder has been prominent. Animal modeling of blast-related TBI has developed rapidly over the last decade leading to advances in the understanding of blast pathophysiology. However, most studies have focused on acute to subacute effects of blast on the nervous system and have typically studied higher intensity blast exposures with energies more comparable to that involved in human moderate to severe TBI. Fewer animal studies have addressed the chronic effects of lower level blast exposures that are more comparable to those involved in human mTBI or subclinical blast. Here we describe a rat model of repetitive low-level blast exposure that induces a variety of anxiety and PTSD-related behavioral traits including exaggerated fear responses that were present when animals were tested between 28 and 35 weeks after the last blast exposure. These animals provide a model to study the chronic and persistent behavioral effects of blast including the relationship of PTSD to mTBI in dual diagnosis veterans.