Familial occurrence of autoimmune diseases and autoantibodies in a Caucasian population of patients with systemic lupus erythematosus
Familial occurrence of autoimmune diseases and autoantibodies in a Caucasian population of patients with systemic lupus erythematosus
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DOI：
10.1007/pl00011215
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发表时间：
2002-05-01
影响因子：
3.4
通讯作者：
Kallenberg, CGM
中科院分区：
文献类型：
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作者：
Corporaal, S;Bijl, M;Kallenberg, CGM
为了确定自身免疫性疾病和自身抗体在白人系统性红斑狼疮（SLE）患者亲属中的患病率，我们询问了118例患者亲属中自身免疫性疾病的患病率。选择多个SLE家族进行进一步调查：评估是否存在抗核抗体（ANA）、甲状腺抗体和IgM类风湿因子（IgM-RF）。33名患者报告了43名亲属中存在的50种自身免疫性疾病。22个诊断可以被确认（n = 14）或被驳回（n = 8）。SLE患者的家族内聚集性显著。多发性硬化症和类风湿性关节炎似乎也聚集在狼疮患者的家庭中。SLE多病家系29名亲属ANA和甲状腺抗体阳性率分别为24%和44%，与对照组比较差异有显著性（P
To determine the prevalence of autoimmune diseases and autoantibodies in relatives of Caucasian patients with systemic lupus erythematosus (SLE) we questioned 118 patients for the prevalence of autoimmune diseases in their relatives. Multicase SLE families were selected for further investigation: assessment of the presence of antinuclear antibodies (ANA), thyroid antibodies and IgM rheumatoid factor (IgM-RF). Thirty-three patients reported the presence of 50 autoimmune diseases in 43 relatives. Twenty-two diagnoses could be either confirmed (n = 14) or refuted (n = 8). SLE clustered significantly within families of SLE patients. Multiple sclerosis and rheumatoid arthritis also seemed to cluster within families of lupus patients. The prevalence of ANA (24%) and thyroid antibodies (44%) in 29 relatives of multicase SLE families was raised (P