Characterization of oculomotor and visual activities in the primate pedunculopontine tegmental nucleus during visually guided saccade tasks
Characterization of oculomotor and visual activities in the primate pedunculopontine tegmental nucleus during visually guided saccade tasks
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DOI：
10.1111/j.1460-9568.2009.07009.x
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发表时间：
2009-12-01
影响因子：
3.4
通讯作者：
Kobayashi, Yasushi
中科院分区：
文献类型：
--
作者：
Okada, Ken-Ichi;Kobayashi, Yasushi
桥脚被盖核 (PPTN) 与许多视觉运动区域有解剖学联系，包括基底神经节、丘脑、上丘和额叶视野。尽管许多解剖学和生理学研究表明 PPTN 在控制条件行为和联想学习中发挥作用，但 PPTN 神经元的扫视和视觉相关活动的详细特征仍不清楚。我们记录了猴子（Macaca fuscata）在视觉引导扫视任务期间 PPTN 神经元的活动，并检查了扫视和视觉相关活动的响应特性，例如时间进程、方向选择性和上下文调制。与扫视相关的活动发生在扫视执行期间或扫视结束之后。神经元活动的首选方向偏向对侧和向上侧。一半与眼跳相关的神经元仅表现出针对任务眼跳的活动调节，而不针对任务外的自发眼跳。视觉反应神经元的反应潜伏期很短。有些以定向选择性的方式对视觉刺激的出现做出反应，而另一些则以定向非选择性的方式对视觉刺激的出现和消失做出反应。这些神经元中的许多神经元对在任务的不同阶段出现的两种不同刺激的出现表现出不同的视觉反应，而神经元群体对两种刺激的消失做出相同的反应。因此，许多 PPTN 神经元表现出与视觉运动事件相关的环境依赖性活动，这与控制条件行为的作用一致。
The pedunculopontine tegmental nucleus (PPTN) has anatomical connections with numerous visuomotor areas including the basal ganglia, thalamus, superior colliculus and frontal eye field. Although many anatomical and physiological studies suggest a role for the PPTN in the control of conditioned behavior and associative learning, the detailed characteristics of saccade- and visual-related activities of PPTN neurons remain unclear. We recorded the activity of PPTN neurons in monkeys (Macaca fuscata ) during visually guided saccade tasks, and examined the response properties of saccade- and visual-related activities such as time course, direction selectivity and contextual modulation. Saccade-related activity occurred either during saccade execution or after saccade end. The preferred directions of the neuronal activity were biased toward the contralateral and upward sides. Half of the saccade-related neurons showed activity modulation only for task saccades and not for spontaneous saccades outside the task. Visually-responsive neurons responded with short latencies. Some responded to the appearance of the visual stimulus in a directionally selective manner, and others responded to both the appearance and disappearance of the visual stimulus in a directionally non-selective manner. Many of these neurons exhibited distinct visual responses to the appearance of two different stimuli presented under different stages of the task, whereas a population of the neurons responded equally to the disappearance of the two stimuli. Thus, many PPTN neurons exhibited context-dependent activity related to the visuomotor events, consistent with a role in controlling conditioned behavior.