C-Terminal Fibroblast Growth Factor 23, Iron Deficiency, and Mortality in Renal Transplant Recipients
C-Terminal Fibroblast Growth Factor 23, Iron Deficiency, and Mortality in Renal Transplant Recipients
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DOI：
10.1681/asn.2016121350
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发表时间：
2017-12-01
影响因子：
13.6
通讯作者：
Gaillard, Carlo A. J. M.
中科院分区：
文献类型：
--
作者：
Eisenga, Michele F.;van Londen, Marco;Gaillard, Carlo A. J. M.
缺铁（ID）与肾移植受者（RTRs）死亡风险增加独立相关。ID促进完整成纤维细胞生长因子23（iFGF 23）的产生和裂解为C-末端成纤维细胞生长因子23（cFGF 23），其水平升高也与不良结局相关。我们假设在RTRs中，ID和死亡率之间的关系是由FGF 23介导的。我们测量了700例稳定RTR患者的血浆iFGF 23和cFGF 23水平，移植后中位数为5.4年。有ID的RTR的中位（四分位距）cFGF 23浓度高于无ID的RTR（223 [131-361] vs 124 [88-180] RU/ml; P
Iron deficiency (ID) is independently associated with an increased risk of death in renal transplant recipients (RTRs). ID promotes production and cleavage of intact fibroblast growth factor 23 (iFGF23) into C-terminal fibroblast growth factor 23 (cFGF23), elevated levels of which are also prospectively associated with adverse outcomes. We hypothesized that in RTRs, the relationship between ID and mortality is mediated by FGF23. We measured plasma iFGF23 and cFGF23 levels in 700 stable RTRs at a median of 5.4 years after transplant. RTRs with ID had median (interquartile range) cFGF23 concentrations higher than those of RTRs without ID (223 [131-361] versus 124 [88-180] RU/ml; P