Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue.
Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue.
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DOI：
10.1186/1471-230x-9-36
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发表时间：
2009-05-20
影响因子：
2.4
通讯作者：
Suleyman H
中科院分区：
文献类型：
--
作者：
Dursun H;Bilici M;Albayrak F;Ozturk C;Saglam MB;Alp HH;Suleyman H
虽然有许多药物可用于治疗胃溃疡，但这些药物往往无效。许多抗抑郁药物在各种实验性溃疡模型中显示出抗溃疡活性。其中一种药物，抗抑郁药米氮平，据报道具有抗溃疡作用，包括抗氧化剂的增加和氧化剂参数的减少。然而，到目前为止，还没有关于类似抗抑郁药氟伏沙明抗溃疡活性的信息。本研究旨在探讨氟伏沙明的抗溃疡作用，并确定其与抗氧化剂的关系。各组禁食24 h大鼠分别灌胃氟伏沙明（25、50、100、200 mg/kg）、雷尼替丁（50 mg/kg）或蒸馏水。吲哚美辛（25 mg/kg）作为溃疡剂口服给药。溃疡诱导6小时后，切除大鼠胃，测定溃疡指数。各组大鼠分别服用相同剂量的氟伏沙明和雷尼替丁，但不服用吲哚美辛，以测试单独使用这些药物对生化参数的影响。对胃进行生化评价，以确定其氧化和抗氧化参数。我们使用单因素方差分析和最小显著性差异（LSD）选项进行数据分析。氟伏沙明25、50、100和200 mg/kg剂量组的抗溃疡效果分别为对照组的48.5、67.5、82.1和96.1%。雷尼替丁的抗溃疡效果为86.5%。在不使用吲哚美辛治疗任何剂量的氟伏沙明或雷尼替丁的情况下，没有观察到差异。与仅使用消炎痛组相比，氟伏沙明组和雷尼替丁组抗氧化参数总谷胱甘肽和一氧化氮水平均升高。此外，氟伏沙明和雷尼替丁与吲哚美辛组相比，降低了大鼠胃组织中氧化参数髓过氧化物酶和丙二醛的水平。我们得出结论，氟伏沙明具有抗溃疡作用，而这些作用是通过激活抗氧化参数和抑制某些有毒氧化参数的机制发生的。
Although many drugs are available for the treatment of gastric ulcers, often these drugs are ineffective. Many antidepressant drugs have been shown to have antiulcer activity in various models of experimental ulcer. One such drug, the antidepressant mirtazapine, has been reported to have an antiulcer effect that involves an increase in antioxidant, and a decrease in oxidant, parameters. To date, however, there is no information available regarding the antiulcer activity for a similar antidepressant, fluvoxamine. This study aimed to investigate the antiulcer effects of fluvoxamine and to determine its relationship with antioxidants. Groups of rats fasted for 24 h received fluvoxamine (25, 50, 100 and 200 mg/kg), ranitidine (50 mg/kg) or distilled water by oral gavage. Indomethacin (25 mg/kg) was orally administered to the rats as an ulcerative agent. Six hours after ulcer induction, the stomachs of the rats were excised and an ulcer index determined. Separate groups of rats were treated with the same doses of fluvoxamine and ranitidine, but not with indomethacin, to test effects of these drugs alone on biochemical parameters. The stomachs were evaluated biochemically to determine oxidant and antioxidant parameters. We used one-way ANOVA and least significant difference (LSD) options for data analysis. The 25, 50, 100 and 200 mg/kg doses of fluvoxamine exerted antiulcer effects of 48.5, 67.5, 82.1 and 96.1%, respectively, compared to the control rat group. Ranitidine showed an 86.5% antiulcer effect. No differences were observed in the absence of indomethacin treatment for any dose of fluvoxamine or for ranitidine. The levels of antioxidant parameters, total glutathione and nitric oxide, were increased in all fluvoxamine groups and in the ranitidine group when compared with the indomethacin-only group. In addition, fluvoxamine and ranitidine decreased the levels of the oxidant parameters, myeloperoxidase and malondialdeyhyde, in the stomach tissues of the rats when compared to indomethacin group. We conclude that fluvoxamine has antiulcer effects, and that these occur by a mechanism that involves activation of antioxidant parameters and inhibition of some toxic oxidant parameters.