Platelet-Neutrophil Interaction and Thromboinflammation in Diabetes: Considerations for Novel Therapeutic Approaches.
Platelet-Neutrophil Interaction and Thromboinflammation in Diabetes: Considerations for Novel Therapeutic Approaches.
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DOI：
10.1161/jaha.122.027071
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发表时间：
2022-10-18
影响因子：
5.4
通讯作者：
Ariens, Robert A. S.
中科院分区：
文献类型：
--
作者：
Gauer, Julia S.;Ajjan, Ramzi A.;Ariens, Robert A. S.
由于糖尿病中血栓形成和炎症之间的相互作用，血栓炎症已成为心血管疾病和糖尿病并发症预防的关键兴趣话题。具体而言，糖尿病血管血栓性疾病的显著风险突出了对新的和更好的治疗靶点的需求，以帮助管理和预防这种情况下的血管血栓闭塞性疾病。同样，炎症在糖尿病中的突出作用引发了人们对抗炎剂的兴趣，以更好地预防和控制血管疾病。对糖尿病和心血管疾病患者抗凝和抗血小板干预的研究表明，这些药物在降低发病率和死亡率方面具有潜在作用。中性粒细胞和血小板分别是炎症和伤口愈合反应的关键参与者。中性粒细胞和血小板之间的相互作用被认为是血栓炎症的重要驱动因素。因此，本文综述了血小板-中性粒细胞相互作用的机制，有助于发展或糖尿病及其相关的合并症的背景下血栓炎症的恶化。抗血栓/抗糖尿病治疗和体力活动/饮食干预对减轻血栓炎症的影响进行了讨论。这些数据表明，血小板-中性粒细胞相互作用、血小板活化/聚集和中性粒细胞募集中涉及的机制有希望成为减少糖尿病患者血栓炎症的治疗靶点。
Thromboinflammation has become a topic of key interest in cardiovascular disease and the prevention of diabetes complications because of the interplay between thrombosis and inflammation in diabetes. Specifically, the significant risk of vascular thrombotic disease in diabetes highlights the need for new and better therapeutic targets to help manage and prevent vascular thrombo‐occlusive disease in this condition. Similarly, the prominent role of inflammation in diabetes has sparked interest in anti‐inflammatory agents to better prevent and control vascular disease. Investigations on the effects of anticoagulation and antiplatelet interventions in patients with diabetes and cardiovascular disease show a potential role for these agents in decreasing morbidity and mortality. Neutrophils and platelets are key players in inflammation and wound‐healing response, respectively. The interaction between neutrophils and platelets is thought to be an important driver of thromboinflammation. Therefore, this review describes the mechanisms involved in platelet–neutrophil interactions that contribute to the development or exacerbation of thromboinflammation in the context of diabetes and its associated comorbidities. The effects observed by the antithrombotic/antidiabetic treatments and physical activity/dietary interventions on attenuating thromboinflammation are discussed. These data suggest that mechanisms involved in platelet–neutrophil interaction, platelet activation/aggregation, and the recruitment of neutrophils have a promising potential to become therapeutic targets to decrease thromboinflammation in patients with diabetes.