Metabolic syndrome throughout the menopausal transition: influence of age and menopausal status
Metabolic syndrome throughout the menopausal transition: influence of age and menopausal status
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DOI：
10.1080/13697130500487331
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发表时间：
2006-02-01
期刊：
影响因子：
2.8
通讯作者：
Berg, GA
中科院分区：
文献类型：
--
作者：
Mesch, VR;Boero, LE;Berg, GA
目的探讨绝经过渡期代谢综合征（MS）和胰岛素抵抗（IR）的主要成分与绝经状态的关系。第二组为绝经过渡期闭经3-6个月（MTA）妇女29例。第三组包括31名绝经后妇女（PostM），第四组包括29名绝经前妇女（PreM）。根据ATP III标准评价代谢综合征。采用HOMA、QUICKI、McAuley指数及甘油三酯/高密度脂蛋白（HDL）比值评价胰岛素抵抗。结果与PreM组相比，MTM、MTA和PostM组的甘油三酯/HDL比值升高。与PreM女性相比，在MTM、MTA和PostM女性中观察到QUIKI指数轻微下降（p = 0.06）和McAuley指数下降（p < 0.001）。四组中代谢综合征的相对频率分别为：PreM，0%; MTM，20%; MTA，21%; PostM，22%（p = 0.0001）。代谢综合征最常见的标志物是腰围增加、高密度脂蛋白胆固醇水平降低和高血压。绝经状态和代谢综合征之间的线性回归丢失时，年龄被添加到model.Conclusions代谢综合征的频率增加的绝经过渡到绝经后的时间。腹部肥胖是观察到的最常见特征。然而，衰老消除了更年期对代谢综合征的影响。为了预防心血管疾病，必须从绝经过渡期开始评估代谢综合征。
Objective To assess the relationship between the main components of both the metabolic syndrome and insulin resistance and menopausal status in the menopausal transition.Methods A total of 124 healthy women were divided into four groups according to their menstrual status: the first group consisted of 35 women in menopausal transition with menstrual bleeding (MTM) and with cycles between 35 and 80 days; the second group was composed of 29 women in menopausal transition with 3-6 months of amenorrhea (MTA). The third group consisted of 31 postmenopausal women (PostM) and the fourth group of 29 premenopausal women (PreM) with regular cycles. The metabolic syndrome was evaluated following the ATP III criteria. Evaluation of insulin resistance was made through the HOMA, QUICKI and McAuley indices and the triglycerides/high density lipoprotein (HDL) cholesterol ratio.Results The triglycerides/HDL cholesterol ratio increased in MTM, MTA and PostM women in comparison with PreM women. A slight decrease in the QUIKI index (p = 0.06) and a decrease in the McAuley index (p < 0.001) were observed in MTM, MTA and PostM women in comparison to PreM women. The relative frequencies of metabolic syndrome in the four groups were: PreM, 0%; MTM, 20%; MTA, 21%; and PostM, 22% (p = 0.0001). The most frequent markers of the metabolic syndrome were increased waist circumference, low HDL cholesterol levels and hypertension. Linear regression between menopausal status and metabolic syndrome was lost when age was added to the model.Conclusions The frequency of metabolic syndrome increased from the time of the menopausal transition to the postmenopause. Abdominal obesity was the most frequent feature observed. Nevertheless, aging erased the effect of the menopause on the metabolic syndrome. In order to prevent cardiovascular disease, the metabolic syndrome must be evaluated from the time of the menopausal transition.