The p75 neurotrophin receptor is localized to primary cilia in adult murine hippocampal dentate gyrus granule cells
The p75 neurotrophin receptor is localized to primary cilia in adult murine hippocampal dentate gyrus granule cells
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DOI：
10.1016/j.bbrc.2010.09.081
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发表时间：
2010-10-22
影响因子：
3.1
通讯作者：
Whitfield, James
中科院分区：
文献类型：
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作者：
Chakravarthy, Balu;Gaudet, Chantal;Whitfield, James
成年鼠海马齿状回的密集纤毛颗粒细胞层是成年神经发生的两个部位之一。颗粒细胞已被证明将其 SSTR3（生长抑素受体 3）受体定位于其所谓的初级纤毛。在这里，我们首次表明，7-18 个月大的野生型和 3 x Tg-AD（阿尔茨海默病转基因）小鼠中 70-90% 的细胞也将 p75(NTR) 受体加载到含有 SSTR3 的结构中，即它们的初级纤毛。另一方面，p75(NTR')s TrkA 辅助受体并不局限于纤毛，而是通常分布在整个细胞表面。海马 CA1 和 CA3 区域以及大脑皮层中含有纤毛的 p75(NTR) 细胞明显减少 (20-40%)。虽然我们不知道 p75(NTR) 的纤毛定位对成年齿状回神经发生和记忆编码的影响可能是什么，但纤毛的淀粉样β-激活 p75(NTR) 受体可能会损害或致命淀粉样β-积累的阿尔茨海默脑的海马功能。 Crown 版权所有 (C) 2010 由 Elsevier Inc. 出版。保留所有权利。
The densely ciliated granule cell layer of the adult murine hippocampal dentate gyrus is one of two sites of adult neurogenesis. The granule cells have already been proven to localize their SSTR3 (somatostatin receptor 3) receptors to their so-called primary cilia. Here we show for the first time that 70-90% of these cells in 7-18 months-old wild-type and 3 x Tg-AD (Alzheimer disease transgenic) mice also load p75(NTR) receptors into the structures containing SSTR3, i.e., their primary cilia. On the other hand, p75(NTR')s TrkA co-receptors were not localized to cilia but conventionally distributed throughout the cell surface. Significantly fewer cells (20-40%) in the hippocampal CA1 and CA3 regions and cerebral cortex have p75(NTR) containing cilia. While we don't know what the impact of the cilial localization of p75(NTR) on dentate gyral adult neurogenesis and memory encoding might be, the cilia's amyloid beta-activatable p75(NTR) receptors could be damaging or lethal to the hippocampal functioning of amyloid beta-accumulating Alzheimer brain. Crown Copyright (C) 2010 Published by Elsevier Inc. All rights reserved.