Cerebellar cortical molecular layer inhibition is organized in parasagittal zones
Cerebellar cortical molecular layer inhibition is organized in parasagittal zones
复制标题
DOI：
10.1523/jneurosci.2434-06.2006
复制
发表时间：
2006-08-09
影响因子：
5.3
通讯作者：
Ebner, Timothy J.
中科院分区：
文献类型：
--
作者：
Gao, Wangcai;Chen, Gang;Ebner, Timothy J.
分子层抑制性中间神经元在小脑皮质产生束上和束外抑制，这被假设为控制浦肯野细胞放电的时间和/或空间模式。已假设在束和离束抑制在叶内是空间均匀和连续的。使用黄素蛋白自体荧光光学成像在小鼠小脑皮质在体内，这项研究表明，平行纤维和外周刺激引起的抑制的结果在parasoprotein带的荧光减少，对应于zeolite II阳性带。GABA（A）拮抗剂可消除荧光减弱的旁带，反映了分子层中间神经元对其靶点的活性。使用Ca 2+成像观察到相同的带型。这些条带在对外围输入的响应中产生空间特异性降低。因此，分子层抑制被划分成zepsin II parasepsin域，差异调节小脑皮质活动的空间模式。
Molecular layer inhibitory interneurons generate on-beam and off-beam inhibition in the cerebellar cortex that is hypothesized to control the timing and/or spatial patterning of Purkinje cell discharge. On-and off-beam inhibition has been assumed to be spatially uniform and continuous within a folium. Using flavoprotein autofluorescence optical imaging in the mouse cerebellar cortex in vivo, this study demonstrates that the inhibition evoked by parallel fiber and peripheral stimulation results in parasagittal bands of decreases in fluorescence that correspond to zebrin II-positive bands. The parasagittal bands of decreased fluorescence are abolished by GABA(A) antagonists and reflect the activity of molecular layer interneurons on their targets. The same banding pattern was observed using Ca2+ imaging. The bands produce spatially specific decreases in the responses to peripheral input. Therefore, molecular layer inhibition is compartmentalized into zebrin II parasagittal domains that differentially modulate the spatial pattern of cerebellar cortical activity.