C-reactive protein and sleep-disordered breathing
C-reactive protein and sleep-disordered breathing
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DOI：
10.1093/sleep/27.8.1507
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发表时间：
2004-12-15
期刊：
影响因子：
5.6
通讯作者：
Ohayon, MM
中科院分区：
文献类型：
--
作者：
Guilleminault, C;Kirisoglu, C;Ohayon, MM
研究目的：在2个月的时间内，评估新发阻塞性睡眠呼吸暂停综合征（OSAS）、上呼吸道阻力综合征（LIARS）、无重要合并症患者以及正常对照组的血清c反应蛋白（CRP）水平。设计：横断面分析。工作地点：睡眠障碍门诊。患者：239名连续监测对象：诊断为OSAS的156名，诊断为liar的39名，对照组54名。干预措施:没有。测量与结果：收集临床资料（神经内科、内科、耳鼻喉科检查）、体重指数、颈围、臀腰比、Epworth嗜睡量表、3项疲劳量表、睡眠障碍问卷、血清CRP、多导睡眠图。方差分析显示两组间舒张压、呼吸障碍指数、最低SaO(2)和体重指数有显著差异。三组患者血清CRP水平均正常。239例受试者中只有15例（14例OSAS和1例UARS）血清CRP值高。CRP水平与体重指数、食管压、臀腰比、颈围和血压显著相关。只有身体质量指数与高CRP值显著相关；多元回归显示：调整后R-2 = 0.115, beta = 0.345, P < 0.001。当男性和女性被分开考虑时，身体质量指数再次与高CRP水平显著相关。结论：与一般人群一样，肥胖是睡眠呼吸障碍患者血清CRP水平升高的一个危险因素。
Study Objectives: Over a 2-month period, to evaluate serum levels of C-reactive protein (CRP) in new patients with obstructive sleep apnea syndrome (OSAS), upper airway resistance syndrome (LIARS), and absence of important comorbidity, as well as in normal controls.Design: Cross-sectional analysis.Setting: Sleep disorders clinic.Patients: 239 successively monitored subjects: 156 subjects were diagnosed with OSAS, 39 with LIARS, and 54 controls.Interventions: none.Measurements and Results: Clinical information (neurologic, general medical, and otolaryngology examination), body mass index, neck circumference, hip-waist ratio, Epworth Sleepiness Scale, 3 fatigue scales, Sleep Disorders Questionnaire, serum CRP, and polysomnography were collected. Analysis of variance indicated a significant difference between the groups for diastolic blood pressure, respiratory disturbance index, lowest SaO(2), and body mass index. The mean serum CRP level was normal in all 3 groups. Only 15 (14 OSAS and 1 UARS) out of 239 subjects had high serum CRP values. CRP levels were significantly correlaed with body mass index, esophageal pressures, hip-waist ratio, neck circumference, and blood pressure. Only body mass index was signifcantly associated with high CRP values; multiple regression showed: adjusted R-2 = 0.115, beta = 0.345, P < .001. When men and women were considered separately, body mass index teas again significantly associated with high CRP levels.Conclusion: Obesity is a risk factor for high serum CRP levels in patients with sleep-disordered breathing, as in the general population.