Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias.
Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias.
复制标题
视黄酸受体α基因在急性寄生虫细胞白血病中的重排和异常表达。
DOI：
10.1084/jem.172.6.1571
复制
发表时间：
1990-12-01
影响因子：
15.3
通讯作者：
Tabilio, A
中科院分区：
文献类型：
--
作者：
Longo, L;Pandolfi, P P;Biondi, A;Rambaldi, A;Mencarelli, A;Lo Coco, F;Diverio, D;Pegoraro, L;Avanzi, G;Tabilio, A
虽然急性早幼粒细胞白血病（APLs）一直与15号染色体相互易位，直接受断点的基因从未被分离。17号染色体断点映射到视黄酸受体α（RAR α）基因座附近。对20例APL和大量其他肿瘤患者和正常对照的研究显示，RAR α基因重排和异常转录仅在APL病例中出现。这些发现表明RAR α基因参与APL染色体17断裂点，与白血病发生有关，并可用作识别白血病早幼粒细胞的标志物。
Although acute promyelocytic leukemias (APLs) are consistently associated with a reciprocal chromosome 15;17 translocation, the gene(s) directly affected by the breakpoints have never been isolated. The chromosome 17 breakpoint maps to near the retinoic acid receptor alpha (RAR alpha) locus. Investigation of 20 APLs and a large series of other neoplastic patients and normal controls revealed RAR alpha gene rearrangements and aberrant transcripts only in the APL cases. These findings suggest that the RAR alpha gene is involved in the APL chromosome 17 breakpoint, is implicated in leukemogenesis, and could be used as a marker for identifying leukemic promyelocytes.