Proliferative verrucous leukoplakia: A proposal for diagnostic criteria
Proliferative verrucous leukoplakia: A proposal for diagnostic criteria
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DOI：
10.4317/medoral.15.e839
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发表时间：
2010-11-01
影响因子：
2.2
通讯作者：
Bagan, Jose V.
中科院分区：
文献类型：
--
作者：
Cerero-Lapiedra, Rocio;Balade-Martinez, David;Bagan, Jose V.
复发性疣状白斑（PVL）是一种罕见的口腔白斑，1985年由汉森等首次报道，由于其高复发率和高恶变率（通常高于70%），各种已发表的病例系列报道均将其描述为一种具有侵袭性生物学行为的疾病。PVL是一种长期进展性疾病，在诊断时60岁以上的女性和老年患者中更常见。最终，PVL倾向于成为多灶性，病变逐渐恶化，使其越来越难以控制。烟草使用似乎对PVL的出现或进展没有显著影响。这些病变可能发生在吸烟者和非吸烟者。然而，目前PVL的病因、治疗和诊断尚不清楚，仍是回顾性的、晚期的、定义不明确的，缺乏共识的标准，因此，本研究的目的是提出一套诊断标准，以便早期和客观地识别PVL病例，从而进行适当的治疗。该建议包括五个主要标准和四个次要标准，以及它们之间的特定组合，以建立正确和客观的诊断增生性疣状白斑。
Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behaviour due to its high probability of recurrence and a high rate of malignant transformation, usually higher than 70%. PVL is a long-term progressive condition, which is observed more frequently in women and elderly patients over 60 years at the time of diagnosis. Eventually, PVL tends to become multifocal with a progressive deterioration of the lesions, making it more and more difficult to control. Tobacco use does not seem to have a significant influence on the appearance or progression of PVL. These lesions may occur both in smokers and nonsmokers. Nevertheless, at present, the aetiology of PVL remains unclear as well as its management and diagnosis, which is still retrospective, late and poorly defined, lacking consensus criteria.Therefore, the aim of this study is to propose a set of diagnostic criteria to allow for the early and objective identification of PVL cases, and thereby conduct an adequate management. The proposal includes five major criteria and four minor criteria, as well as specific combinations among them in order to establish a correct and objective diagnosis of proliferative verrucous leukoplakia.