Increased number of microinfarcts in Alzheimer disease at 7-T MR imaging.
Increased number of microinfarcts in Alzheimer disease at 7-T MR imaging.
复制标题
7-T MR 成像中阿尔茨海默病的微梗塞数量增加。
DOI：
10.1148/radiol.13130743
复制
发表时间：
2013
期刊：
影响因子：
19.7
通讯作者：
J. van der Grond
中科院分区：
文献类型：
--
作者：
S. van Rooden;J. Goos;A. M. van Opstal;M. Versluis;A. Webb;G. Blauw;W. M. van der Flier;P. Scheltens;F. Barkhof;M. van Buchem;J. van der Grond
目的
通过使用7-T磁共振（MR）成像系统评估阿尔茨海默病（AD）患者中皮质微梗死的患病率和数量，评估皮质微梗死与认知功能障碍的独立相关性，并研究脑淀粉样血管病（CAA）共存的潜在混杂效应。
材料和方法
当地机构审查委员会批准了本研究。所有病例均获得知情同意。高空间分辨率液体衰减反转恢复和T2* 加权图像采集14例AD患者和18例对照组，以评估微梗死和微出血的存在。根据波士顿标准评估CAA的存在。图像分析由两名评审员独立进行。进行Mann-Whitney U检验以评估组间微梗死数量的差异。负二项回归模型用于评估AD诊断和CAA诊断与微梗死数量之间的关联，AD诊断与微出血数量和微梗死数量之间的关联，以及认知功能与微梗死数量之间的关联，所有这些均经年龄和性别校正。
结果
观察者间检测微梗死的一致性非常好（κ = 0.91）（P < .001）。与对照组（平均1.8）相比，AD患者表现出更高数量（P = 0.005）的微梗死（平均7.2）。负二项回归模型显示AD与微梗死数量之间存在独立相关性（P = 0.006），CAA与微梗死存在趋势（P = 0.052）。认知功能与微梗死数量呈负相关（P = 0.009）。
结论
AD患者比对照组显示更多的微梗死，微梗死的数量与整体认知能力相关，并且微梗死的存在主要与AD而不是CAA相关。
PURPOSE
To assess the prevalence and number of cortical microinfarcts in patients with Alzheimer disease (AD) by using a 7-T magnetic resonance (MR) imaging system, to assess the independent association of cortical microinfarcts with cognitive dysfunction, and to investigate potential confounding effects of the coexisting presence of cerebral amyloid angiopathy (CAA).
MATERIALS AND METHODS
The local institutional review board approved this study. In all cases, informed consent was obtained. High-spatial-resolution fluid-attenuated inversion recovery and T2*-weighted images were acquired in 14 AD patients and 18 control subjects to assess the presence of microinfarcts and microbleeds. Presence of CAA was assessed according to the Boston criteria. Image analysis was performed independently by two reviewers. Mann-Whitney U test was performed to assess differences in number of microinfarcts between groups. Negative binomial regression models were used to assess the association between diagnosis of AD and diagnosis of CAA and number of microinfarcts, between diagnosis of AD and number of microbleeds and number of microinfarcts, and between cognitive function and number of microinfarcts, all corrected for age and sex.
RESULTS
Interobserver agreement was excellent for detecting microinfarcts (κ = 0.91) (P < .001). Patients with AD demonstrated higher number (P = .005) of microinfarcts (mean, 7.2) compared with control subjects (mean, 1.8). Negative binomial regression models showed an independent association between AD and number of microinfarcts (P = .006) and a trend for CAA and microinfarcts (P = .052). A negative correlation was found between cognitive function and the number of microinfarcts (P = .009).
CONCLUSION
Patients with AD show more microinfarcts than do control subjects, the number of microinfarcts correlates with global cognitive performance, and the presence of microinfarcts was mainly AD rather than CAA related.
影响因子：
--
作者：
Sonnen, Joshua A.;Cruz, Karen Santa;Hemmy, Laura S.;Woltjer, Randall;Leverenz, James B.;Montine, Kathleen S.;Jack, Clifford R.;Kaye, Jeffrey;Lim, Kelvin;Larson, Eric B.;White, Lon;Montine, Thomas J.
通讯作者：
Montine, Thomas J.