Varian ethos online adaptive radiotherapy for prostate cancer: Early results of contouring accuracy, treatment plan quality, and treatment time.
Varian ethos online adaptive radiotherapy for prostate cancer: Early results of contouring accuracy, treatment plan quality, and treatment time.
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DOI：
10.1002/acm2.13479
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发表时间：
2022-01
影响因子：
2.1
通讯作者：
Aland T
中科院分区：
文献类型：
--
作者：
Byrne M;Archibald-Heeren B;Hu Y;Teh A;Beserminji R;Cai E;Liu G;Yates A;Rijken J;Collett N;Aland T
Varian Ethos系统允许通过利用人工智能（AI）和可变形图像配准进行在线自适应治疗，可使大部分解剖轮廓绘制和计划优化过程自动化。在这项研究中，完整的前列腺和前列腺床的治疗，有和没有节点，模拟了182个在线自适应分数，然后在Ethos系统上提供了另外184个临床分数。记录轮廓编辑的频率和幅度，以及一系列计划质量指标。从分析的分数中，11%的AI生成的轮廓（称为影响者轮廓）不需要更改，81%的轮廓需要在任何给定的分数中进行微小的编辑。靶器官和非影响器官（OAR）轮廓编辑的频率在不同靶器官和非影响器官OAR之间差异很大，尽管在所有靶器官中，72%的病例不需要编辑。适应性方案在95%的分数中是首选。在78%的分数中，自适应计划比预定计划达到更多的目标，而在15%的分数中，达到的目标数量相同。在线自适应重新轮廓和重新规划过程平均在19分钟内完成。在前列腺放射治疗中，Ethos在线自适应系统可以显著改善剂量测定。
The Varian Ethos system allows for online adaptive treatments through the utilization of artificial intelligence (AI) and deformable image registration which automates large parts of the anatomical contouring and plan optimization process. In this study, treatments of intact prostate and prostate bed, with and without nodes, were simulated for 182 online adaptive fractions, and then a further 184 clinical fractions were delivered on the Ethos system. Frequency and magnitude of contour edits were recorded, as well as a range of plan quality metrics. From the fractions analyzed, 11% of AI generated contours, known as influencer contours, required no change, and 81% required minor edits in any given fraction. The frequency of target and noninfluencer organs at risk (OAR) contour editing varied substantially between different targets and noninfluencer OARs, although across all targets 72% of cases required no edits. The adaptive plan was the preference in 95% of fractions. The adaptive plan met more goals than the scheduled plan in 78% of fractions, while in 15% of fractions the number of goals met was the same. The online adaptive recontouring and replanning process was carried out in 19 min on average. Significant improvements in dosimetry are possible with the Ethos online adaptive system in prostate radiotherapy.
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DOI：
10.1186/s13014-021-01866-7
发表时间：
2021-07-23
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
de Jong R;Visser J;van Wieringen N;Wiersma J;Geijsen D;Bel A
通讯作者：
Bel A
影响因子：
2.1
作者：
Hu Y;Byrne M;Archibald-Heeren B;Collett N;Liu G;Aland T
通讯作者：
Aland T
影响因子：
3.8
作者：
Liu, Han;Wu, Qiuwen
通讯作者：
Wu, Qiuwen
影响因子：
1.2
作者：
Aland, Trent;Walsh, Anthony;Devlin, Aimee
通讯作者：
Devlin, Aimee
DOI：
10.1016/j.ijrobp.2009.10.013
发表时间：
2010-08-01
影响因子：
7
作者：
Ahunbay, Ergun E.;Peng, Cheng;Li, X. Allen
通讯作者：
Li, X. Allen