Drivers of SARS-CoV-2 testing behaviour: a modelling study using nationwide testing data in England.

Drivers of SARS-CoV-2 testing behaviour: a modelling study using nationwide testing data in England.
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SARS-COV-2测试行为的驱动因素:使用英格兰的全国性测试数据进行建模研究。

DOI:
10.1038/s41467-023-37813-1
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发表时间:
2023-04-14
影响因子:
16.6
通讯作者:
Nouvellet, Pierre
Nouvellet, Pierre
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Kim, Younjung;Donnelly, Christl A.;Nouvellet, Pierre

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During the COVID-19 pandemic, national testing programmes were conducted worldwide on unprecedented scales. While testing behaviour is generally recognised as dynamic and complex, current literature demonstrating and quantifying such relationships is scarce, despite its importance for infectious disease surveillance and control. Here, we characterise the impacts of SARS-CoV-2 transmission, disease susceptibility/severity, risk perception, and public health measures on SARS-CoV-2 PCR testing behaviour in England over 20 months of the pandemic, by linking testing trends to underlying epidemic trends and contextual meta-data within a systematic conceptual framework. The best-fitting model describing SARS-CoV-2 PCR testing behaviour explained close to 80% of the total deviance in NHS test data. Testing behaviour showed complex associations with factors reflecting transmission level, disease susceptibility/severity (e.g. age, dominant variant, and vaccination), public health measures (e.g. testing strategies and lockdown), and associated changes in risk perception, varying throughout the pandemic and differing between infected and non-infected people. SARS-CoV-2 testing rates have varied during the pandemic but the drivers of changes in testing behaviour are unclear. Here, the authors link national testing data from England to indicators of epidemic trends to describe how testing varies according to level of virus transmission, disease susceptibility/severity, public health measures, and risk perception.
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