The Prevalence of Substance Use Disorders in American Physicians
The Prevalence of Substance Use Disorders in American Physicians
复制标题
DOI：
10.1111/ajad.12173
复制
发表时间：
2015-01-01
影响因子：
3.7
通讯作者：
Boone, Sonja
中科院分区：
文献类型：
--
作者：
Oreskovich, Michael R.;Shanafelt, Tait;Boone, Sonja
氯胺酮在医学领域以其麻醉特性而闻名，但其独特的致幻剂和抗抑郁剂特性正越来越多地被认可。我们记录了一名患有双相I型障碍和广泛的物质依赖史的患者的病例，该患者在5年的时间内每天使用大剂量氯胺酮（1-3g），并描述了急性抗抑郁作用以及对酒精的渴望减少。虽然他的使用是站不住脚的，并最终导致住院，但值得注意的是，他没有经历戒断综合征，也没有任何可观察到的认知缺陷后停止使用。这种独特的药物特征表明，进一步探索其在治疗情绪和成瘾障碍方面的风险和治疗潜力是必要的。(Am J Addict 2015;24：7-9）
Ketamine is known within the medical field for its anesthetic properties, yet its unique psychedelic and antidepressant properties are being increasingly recognized. We document the case of a patient with bipolar I disorder and an extensive history of substance dependence who used large doses of ketamine (1-3g) on a daily basis over a period of 5 years, and described acute antidepressant effects as well as diminished cravings for alcohol. While his use was untenable and ultimately led to an inpatient admission, it is notable that he did not experience a withdrawal syndrome nor did he have any observable cognitive deficits upon cessation of use. Such a unique drug profile suggests that further exploration of its risks and therapeutic potential in treating mood and addiction disorders is warranted. (Am J Addict 2015;24:7-9)