MicroRNA and cancer--a brief overview.
MicroRNA and cancer--a brief overview.
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DOI：
10.1016/j.jbior.2014.09.013
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发表时间：
2015-01-01
影响因子：
--
通讯作者：
Croce, Carlo M
中科院分区：
文献类型：
--
作者：
Acunzo, Mario;Romano, Giulia;Croce, Carlo M
MicroRNAs(MiRNAs)是一种长度为22个核苷酸的非编码短小RNA，参与基因表达的转录后调控。到目前为止，已经在人类中发现了超过2588个miRNAs，而且这个名单还在不断增长。MicroRNAs在所有的生物学过程中都起着重要的作用，miRNA的异常表达与包括癌症在内的许多疾病有关。2002年，发现了癌症与miRNA解除调控之间的第一个联系。从那时起，关于miRNAs在癌症发生和耐药中扮演的关键角色的信息已经获得了大量的信息。然而，要完全理解miRNA世界，还有很长的路要走。在这篇综述中，我们简要描述了miRNA的生物发生，并讨论了miRNAs在癌症发生和耐药中的作用。最后，我们解释了miRNAs如何被用作癌症的生物标志物和一种新的治疗方法。
MicroRNAs (miRNAs) are short non-coding RNAs with a length of22 nucleotides, involved in posttranscriptional regulation of gene expression. Until now, over 2588 miRNAs have been identified in humans and the list is growing. MicroRNAs have an important role in all biological processes and aberrant miRNA expression is associated with many diseases including cancer. In the year 2002 the first connection between cancer and miRNA deregulation was discovered. Since then, a lot of information about the key role which miRNAs play in cancer development and drug resistance has been gained. However, there is still a long way to go to fully understand the miRNA world. In this review, we briefly describe miRNA biogenesis and discuss the role of miRNAs in cancer development and drug resistance. Finally we explain how miRNAs can be used as biomarkers and as a novel therapeutic approach in cancer.