Selective Roles for Hippocampal, Prefrontal Cortical, and Ventral Striatal Circuits in Radial-Arm Maze Tasks With or Without a Delay
Selective Roles for Hippocampal, Prefrontal Cortical, and Ventral Striatal Circuits in Radial-Arm Maze Tasks With or Without a Delay
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DOI：
10.1523/jneurosci.17-05-01880.1997
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发表时间：
1997-03
期刊：
影响因子：
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通讯作者：
S. Floresco;J. Seamans;A. Phillips
中科院分区：
文献类型：
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作者：
S. Floresco;J. Seamans;A. Phillips
海马体、前额叶皮层和腹侧纹状体形成相互连接的神经回路，这些神经回路可能是空间认知和记忆的基础。在本系列实验中，我们研究了延迟和非延迟空间线索径向臂迷宫任务的性能在大鼠这些领域之间的功能相互作用。两阶段的延迟任务包括一个训练阶段，提供大鼠的信息，食物将位于迷宫30分钟后，在测试阶段。单相nondelayed任务是相同的延迟任务的测试阶段，但在没有一个训练阶段的大鼠缺乏以前的知识的迷宫上的食物的位置。短暂失活的腹侧CA 1/下托（vSub）的双侧注射利多卡因破坏性能的两个任务。利多卡因注射到大脑一侧的vSub和另一侧的前额叶皮层，短暂地断开了这两个大脑区域，并在延迟任务中显著损害了觅食，但在非延迟任务中没有。vSub和脑桥核之间的短暂断开产生了相反的效果，在非延迟任务期间破坏觅食，但在延迟任务期间没有。这些数据表明，串行传输的vSub和前额叶皮层之间的信息时，需要审判独特的，短期记忆是用来指导前瞻性搜索行为。相比之下，探索性的目标导向的运动在一个新的情况下，不需要事先获得的信息的位置的食物是依赖于海马体和脑桥核之间的串行传输。这些结果表明，不同方面的空间介导的行为subserved由单独的，分布式的边缘皮层纹状体网络。
The hippocampus, the prefrontal cortex, and the ventral striatum form interconnected neural circuits that may underlie aspects of spatial cognition and memory. In the present series of experiments, we investigated functional interactions between these areas in rats during the performance of delayed and nondelayed spatially cued radial-arm maze tasks. The two-phase delayed task consisted of a training phase that provided rats with information about where food would be located on the maze 30 min later during a test phase. The single-phase nondelayed task was identical to the test phase of the delayed task, but in the absence of a training phase rats lacked previous knowledge of the location of food on the maze. Transient inactivation of the ventral CA1/subiculum (vSub) by a bilateral injection of lidocaine disrupted performance on both tasks. Lidocaine injections into the vSub on one side of the brain and the prefrontal cortex on the other transiently disconnected these two brain regions and significantly impaired foraging during the delayed task but not the nondelayed task. Transient disconnections between the vSub and the nucleus accumbens produced the opposite effect, disrupting foraging during the nondelayed task but not during the delayed task. These data suggest that serial transmission of information between the vSub and the prefrontal cortex is required when trial-unique, short-term memory is used to guide prospective search behavior. In contrast, exploratory goal-directed locomotion in a novel situation not requiring previously acquired information about the location of food is dependent on serial transmission between the hippocampus and the nucleus accumbens. These results indicate that different aspects of spatially mediated behavior are subserved by separate, distributed limbic–cortical–striatal networks.