Bisphenol A exposure is associated with decreased lung function.
Bisphenol A exposure is associated with decreased lung function.
复制标题
双酚 A 暴露与肺功能下降有关。
DOI：
10.1016/j.jpeds.2014.02.026
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Trasande,Leonardo
中科院分区：
文献类型：
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作者：
Spanier,AdamJ;Fiorino,ElizabethK;Trasande,Leonardo
目的探讨双酚A （BPA）暴露与儿童肺功能指标和呼出一氧化氮（FeNO）的关系。研究设计我们对参加2007-2010年全国健康与营养检查调查的6-19岁美国儿童的子样本进行了横断面分析。我们评估了尿BPA浓度与年龄、性别、种族/民族和身高（1秒用力呼气量[FEV1]、用力肺活量[FVC]、用力呼气流量25%-75%、FEV1除以FVC）和FeNO预测肺功能指标的单变量和多变量关联。结果获得661例儿童的暴露和结局数据。BPA中位数为2.4 ng/mL （IQR: 1.3, 4.1）。在多变量分析中，较高的尿液BPA浓度与预测用力呼气流量25%-75% (%FEF2575) （3.7%, 95% CI 1.0, 6.5）和预测FEV1/FVC (%FEV1/FVC) （0.8%, 95% CI 0.1, 1.7）的百分比显著降低相关，但与预测FEV1、预测FVC或FeNO的百分比无关。BPA浓度最高的儿童FEF2575比最低的儿童降低10% (95% CI - 1, - 19)， FEV1/FVC降低3% （95% CI - 1, - 5）。结论sbpa暴露与%FEF2575（小气道功能）和%FEV1/FVC（肺阻塞）的适度降低有关，但与FEV1、FVC或FeNO无关。对这种联系的解释不能排除反向因果关系的可能性。
ObjectiveTo examine the associations of bisphenol A (BPA) exposure with lung function measures and exhaled nitric oxide (FeNO) in children.Study designWe performed a cross-sectional analysis of a subsample of US children age 6-19 years who participated in the 2007-2010 National Health and Nutrition Examination Survey. We assessed univariate and multivariable associations of urinary BPA concentration with the predicted pulmonary function measures for age, sex, race/ethnicity and height (forced expiratory volume in 1 second [FEV1], forced vital capacity [FVC], forced expiratory flow 25%-75%, and FEV1 divided by FVC) and with FeNO.ResultsExposure and outcome data were available for 661 children. Median BPA was 2.4 ng/mL (IQR: 1.3, 4.1). In multivariable analysis, a larger urinary BPA concentration was associated with significantly decreased percent predicted forced expiratory flow 25%-75% (%FEF2575) (3.7%, 95% CI 1.0, 6.5) and percent predicted FEV1 divided by FVC (%FEV1/FVC) (0.8%, 95% CI 0.1, 1.7) but not percent predicted FEV1, percent predicted FVC, or FeNO. A child in the top quartile of BPA compared with the bottom quartile had a 10% decrease in %FEF2575 (95% CI −1, −19) and 3% decrease in %FEV1/FVC (95% CI −1, −5).ConclusionsBPA exposure was associated with a modest decrease in %FEF2575 (small airway function) and %FEV1/FVC (pulmonary obstruction) but not FEV1, FVC, or FeNO. Explanations of the association cannot rule out the possibility of reverse causality.