DETERMINATION OF SPATIAL DOMAINS OF ZYGOTIC GENE-EXPRESSION IN THE DROSOPHILA EMBRYO BY THE AFFINITY OF BINDING-SITES FOR THE BICOID MORPHOGEN
DETERMINATION OF SPATIAL DOMAINS OF ZYGOTIC GENE-EXPRESSION IN THE DROSOPHILA EMBRYO BY THE AFFINITY OF BINDING-SITES FOR THE BICOID MORPHOGEN
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DOI：
10.1038/340363a0
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发表时间：
1989-08-03
期刊：
影响因子：
64.8
通讯作者：
NUSSLEINVOLHARD, C
中科院分区：
文献类型：
--
作者：
DRIEVER, W;THOMA, G;NUSSLEINVOLHARD, C
母体基因座是决定果蝇胚胎前半部分模式的系统的关键组成部分. Bicoid蛋白在早期胚胎中形成浓度梯度，并且已知结合DNA。特异性结合位点现在被证明赋予表达在胚胎的一个区域，这取决于它们对bicoid蛋白的亲和力：高亲和力的位点允许表达进一步下降bicoid蛋白梯度比低亲和力的位点。
The maternal genebicoidis a key component of the system that determines the pattern of the anterior half ofDrosophilaembryos. The bicoid protein forms a concentration gradient in early embryos, and is known to bind DNA. Specific binding sites are now shown to confer expression in a region of the embryo that depends on their affinity for bicoid protein: sites of high affinity allow expression further down the bicoid protein gradient than sites of low affinity.