Persistent inflammatory, immunosuppressed, catabolic syndrome (PICS): A new phenotype of multiple organ failure.
Persistent inflammatory, immunosuppressed, catabolic syndrome (PICS): A new phenotype of multiple organ failure.
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DOI：
10.14800/janhm.784
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发表时间：
2015-04
期刊：
影响因子：
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通讯作者：
Martin D Rosenthal;F. Moore
中科院分区：
文献类型：
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作者：
Martin D Rosenthal;F. Moore
出现了一种新的多器官衰竭表型：持续性炎症、免疫抑制、分解代谢综合征（PICS）。合并症和年龄 >65 岁已被确定为 PICS 的主要危险因素。随着老年人比例的不断增加，我们 ICU 中 PICS 的患病率肯定会增加。营养不良（尽管进行了适当的补充）、反复出现的院内感染、虚弱、呼吸机依赖和无痛死亡是困扰 PICS 患者的中心主题。与 NIGMS 最近授予的题为“PICS：外科重症监护的新视野”的 P50 拨款相一致，佛罗里达大学脓毒症和危重疾病研究中心将调查 PICS 患者的基因构成，更好地了解虚弱及其对创伤患者的影响，并希望阐明新的疗法。目前，除了在回顾关于烧伤、恶病质和肌肉减少症的文献后详细阐述的营养推断之外，还没有对抗 PICS 的疗法。
A new phenotype of multiple organ failure has appeared: Persistent Inflammatory, Immunosuppressed, Catabolic Syndrome (PICS). Comorbidities and age >65 years have been established as the leading risk factors for PICS. As the percentage of elderly people continues to increase the prevalence of PICS in our ICUs will surely grow. Malnutrition (despite appropriate supplementation), recurrent nosocomial infections, frailty, ventilator dependence, and an indolent death depicts the central theme that plagues PICS patients. Aligned with the recently awarded P50 grant by NIGMS entitled, "PICS: A New Horizon for Surgical Critical Care", and the University Of Florida's Sepsis and Critical Illness Research Center will investigate the genetic make-up of PICS patients, better understand frailty and the implication in trauma patients, and hopefully elucidate new therapies. Currently, there are no therapies to combat PICS aside from nutritional inference elaborated after reviewing the literature on Burns, Cachexia, and Sarcopenia.