Gender differences in a clinical trial for prescription opioid dependence
Gender differences in a clinical trial for prescription opioid dependence
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DOI：
10.1016/j.jsat.2012.12.007
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发表时间：
2013-07-01
影响因子：
3.9
通讯作者：
Weiss, Roger D.
中科院分区：
文献类型：
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作者：
McHugh, R. Kathryn;DeVito, Elise E.;Weiss, Roger D.
尽管在物质使用障碍方面的性别差异已经被发现，但很少有研究考察处方药依赖方面的性别差异。这项研究的目的是在一项针对处方阿片类药物依赖的大型临床试验中，检查临床特征和治疗结果的性别差异。尽管治疗前阿片依赖的严重程度没有差异，但女性报告的功能损害、精神严重程度以及使用阿片类药物应对负面情绪和疼痛的可能性都高于男性。女性也比男性更有可能首先通过合法处方获得阿片类药物，并通过预定的给药途径使用阿片类药物。男性报告的酒精问题明显多于女性。在用药剂量、治疗滞留或阿片类药物结果方面没有显著的性别差异。因此，尽管这一人群在治疗前存在性别差异，但一旦开始研究治疗，女性和男性表现出类似的阿片类药物使用结果。(C)2013 Elsevier Inc.保留所有权利。
Although gender differences in substance use disorders have been identified, few studies have examined gender differences in prescription drug dependence. The aim of this study was to examine gender differences in clinical characteristics and treatment outcomes in a large clinical trial for prescription opioid dependence. Despite no pre-treatment differences in opioid dependence severity, women reported significantly greater functional impairment, greater psychiatric severity, and higher likelihood of using opioids to cope with negative affect and pain than men. Women were also more likely than men to have first obtained opioids via a legitimate prescription and to use opioids via the intended route of administration. Men reported significantly more alcohol problems than women. There were no significant gender differences in medication dose, treatment retention, or opioid outcomes. Thus, despite the presence of pre-treatment gender differences in this population, once the study treatment was initiated, women and men exhibited similar opioid use outcomes. (c) 2013 Elsevier Inc. All rights reserved.