Estrogenic activity of the insecticide kepone on the chicken oviduct.
Estrogenic activity of the insecticide kepone on the chicken oviduct.
复制标题
杀虫剂开普酮对鸡输卵管的雌激素活性。
作者：
R. Palmiter;E. Mulvihill
酮作为弱雌激素诱导鸡输卵管离体组织中卵白蛋白和伴清蛋白的合成。它与核雌激素受体结合，并被抗雌激素他莫昔芬拮抗。开酮还通过与雌激素受体的直接相互作用和通过间接增加血清中孕酮的浓度来诱导体内卵白色蛋白合成。
Kepone induces ovalbumin and conalbumin synthesis in explants of chick oviduct in vitro by acting as a weak estrogen. It binds to the nuclear estrogen receptor and is antagonized by the antiestrogen tamoxifen. Kepone also induces egg white protein synthesis in vivo by direct interaction with estrogen receptors and by indirectly increasing the concentration of progesterone in the serum.