Autoantibodies against platelet membrane glycoproteins in children with acute and chronic immune thrombocytopenic purpura.
Autoantibodies against platelet membrane glycoproteins in children with acute and chronic immune thrombocytopenic purpura.
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DOI：
10.1182/blood.v74.5.1600.bloodjournal7451600
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发表时间：
1989-10
期刊：
影响因子：
20.3
通讯作者：
P. Berchtold;Robert Mcmiiian;P. Tani;Sharon Sommerville-Nielsen;V. Blanchette;Robert Mcmillan Md;V. Woods;Theo-Dore Zimmerman;Zaverio Ruggeni;Scripps
中科院分区：
文献类型：
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作者：
P. Berchtold;Robert Mcmiiian;P. Tani;Sharon Sommerville-Nielsen;V. Blanchette;Robert Mcmillan Md;V. Woods;Theo-Dore Zimmerman;Zaverio Ruggeni;Scripps
成人慢性免疫性血小板减少性紫癜（ITP）的自身免疫性质已被广泛接受。相反，儿童急性和慢性ITP的发病机制尚不清楚。本文对39例破坏性血小板减少症患儿、15例急性ITP和24例慢性ITP进行了研究。慢性ITP组24例患者中有14例（58.3%）和急性ITP组15例患者中有4例（26.7%）检测到血小板糖蛋白IIb/IIIa的血小板自身抗体。与急性ITP患者相比，慢性ITP患者阳性患者的结合率（+/- SD）显著更高（P = 0.01）（8.0 +/- 9.1），急性ITP患者的结合率仅略高于正常范围（1.9 +/- 0.4）。结果表明，抗血小板糖蛋白的自身抗体存在于大多数儿童慢性ITP确认这种疾病的自身免疫性质。在急性ITP阳性儿童中观察到的最小升高提示不同的发病机制。这些数据表明，这种方法可能有助于区分急性和慢性ITP患者。
The autoimmune nature of chronic immune thrombocytopenic purpura (ITP) in adults is widely accepted. In contrast, the pathogenetic mechanism in acute and chronic ITP in children is not known. In this report, we studied 39 children with destructive thrombocytopenia, 15 patients with acute ITP and 24 patients with chronic ITP. Platelet autoantibodies to platelet glycoprotein IIb/IIIa were detected in 14 of 24 patients (58.3%) in the chronic ITP group and in four of 15 (26.7%) with acute ITP. Binding ratios (+/- SD) of positive patients were significantly greater (P = .01) in chronic ITP (8.0 +/- 9.1) when compared with those of acute ITP where the binding ratios were only slightly above the normal range (1.9 +/- 0.4). The results show that autoantibodies against platelet glycoproteins are present in the majority of children with chronic ITP confirming the autoimmune nature of this disorder. The minimal elevation seen in the positive children with acute ITP suggests a different pathogenetic mechanism. These data suggest that this approach may be useful in differentiating acute from chronic ITP patients.