An obesity-associated gut microbiome with increased capacity for energy harvest
An obesity-associated gut microbiome with increased capacity for energy harvest
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DOI：
10.1038/nature05414
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发表时间：
2006-12-21
期刊：
影响因子：
64.8
通讯作者：
Gordon, Jeffrey I.
中科院分区：
文献类型：
--
作者：
Turnbaugh, Peter J.;Ley, Ruth E.;Gordon, Jeffrey I.
世界范围内的肥胖流行正在刺激人们努力确定影响能量平衡的宿主和环境因素。遗传性肥胖小鼠和它们的瘦同窝出生的小鼠以及肥胖和瘦人类志愿者的远端肠道微生物群的比较揭示，肥胖与两种主要细菌部门（拟杆菌门和厚壁菌门）的相对丰度的变化有关。在这里，我们通过宏基因组和生化分析证明，这些变化影响了小鼠肠道微生物群的代谢潜力。我们的研究结果表明，肥胖的微生物组从饮食中获取能量的能力增加。此外，这种特性是可传播的：用“肥胖微生物群”定植无菌小鼠比用“瘦微生物群”定植导致总身体脂肪显著更大的增加。这些结果将肠道微生物群确定为肥胖症病理生理学的额外贡献因素。
The worldwide obesity epidemic is stimulating efforts to identify host and environmental factors that affect energy balance. Comparisons of the distal gut microbiota of genetically obese mice and their lean littermates, as well as those of obese and lean human volunteers have revealed that obesity is associated with changes in the relative abundance of the two dominant bacterial divisions, the Bacteroidetes and the Firmicutes. Here we demonstrate through metagenomic and biochemical analyses that these changes affect the metabolic potential of the mouse gut microbiota. Our results indicate that the obese microbiome has an increased capacity to harvest energy from the diet. Furthermore, this trait is transmissible: colonization of germ-free mice with an `obese microbiota' results in a significantly greater increase in total body fat than colonization with a 'lean microbiota'. These results identify the gut microbiota as an additional contributing factor to the pathophysiology of obesity.