Broad Chromatin Domains: An Important Facet of Genome Regulation
Broad Chromatin Domains: An Important Facet of Genome Regulation
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DOI：
10.1002/bies.201700124
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发表时间：
2017-12-01
期刊：
影响因子：
4
通讯作者：
Ahringer, Julie
中科院分区：
文献类型：
--
作者：
Carelli, Francesco N.;Sharma, Garima;Ahringer, Julie
染色质的组成在整个基因组中是不同的，不同的组成描述了与不同的特性和功能相关的区域。虽然许多组蛋白修饰显示局部富含基因或调节元件，但标记也可以跨越大的基因组间隔，定义广泛的染色质结构域。在这里，我们重点介绍了以组蛋白修饰为标志的染色质结构域的结构和功能特征，特别强调了H3K27甲基化结构域在后生动物基因组活动的组织和调节中的潜在作用。
Chromatin composition differs across the genome, with distinct compositions characterizing regions associated with different properties and functions. Whereas many histone modifications show local enrichment over genes or regulatory elements, marking can also span large genomic intervals defining broad chromatin domains. Here we highlight structural and functional features of chromatin domains marked by histone modifications, with a particular emphasis on the potential roles of H3K27 methylation domains in the organization and regulation of genome activity in metazoans.