FATTY ACID COMPOSITION OF RAT LIVER LIPIDS DURING CHOLINE DEFICIENCY
FATTY ACID COMPOSITION OF RAT LIVER LIPIDS DURING CHOLINE DEFICIENCY
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DOI：
10.1093/jn/86.2.178
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发表时间：
1965-01-01
影响因子：
4.2
通讯作者：
CORNATZER, WE
中科院分区：
文献类型：
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作者：
GLENDE, EA;CORNATZER, WE
在大鼠中测定了全肝甘油三酯、甘油二酯、总磷脂和卵磷脂以及线粒体总磷脂和卵磷脂的脂肪酸组成，这些大鼠在喂食低蛋白、胆碱缺乏饮食10或28天后出现脂肪肝。用氢化植物油或红花油作为膳食脂肪的来源进行实验。总的来说，与接受胆碱补充剂的动物相比，胆碱缺乏动物的肝脏脂质的脂肪酸模式基本上没有差异。然而，在饮食中的脂肪和碳水化合物的类型占胆碱剥夺和胆碱喂养大鼠的脂肪酸组成的变化。氢化植物油，其具有高含量的油酸，导致肝脏脂质油酸含量增加，并产生亚油酸和花生四烯酸水平的降低，而红花油，含有高含量的亚油酸，导致肝脏脂质油酸水平下降，而亚油酸水平几乎保持不变。在棕榈酸和棕榈油酸含量的增加，所有的肝脏脂质分析观察到，这是由于高碳水化合物含量的半纯化饲料。它的结论是，在大鼠胆碱缺乏症的肝脏中性脂质的积累是不伴随着肝脏中性脂质或肝磷脂的脂肪酸模式的变化，可以直接归因于缺乏胆碱。肝脏脂质脂肪组成的变化可能归因于膳食脂肪和膳食碳水化合物水平的变化。
The fatty acid compositions of whole liver triglycerides, diglycerides, total phospholipids, and lecithin and mitochondrial total phospholipids and lecithin were determined on rats which had developed fatty livers after they had been fed a low protein, choline-deficient diet for 10 or 28 days. Experiments were conducted with either a hydro-genated vegetable oil or safflower oil as the source of dietary fat. Over all, there was essentially no difference in the fatty acid patterns of the liver lipids from the choline-deficient animals when compared with those receiving a choline supplement. However, the type of fat and carbohydrate in the diet accounted for changes in the fatty acid composition in both the choline-deprived and choline-fed rats. The hydro-genated vegetable oil, which has a high amount of oleic acid, caused the liver lipid oleic acid content to increase and produced a lowering of the linoleic and arachadonic acid levels, whereas safflower oil, containing a high content of linoleic acid, caused the liver lipid oleic acid level to drop while the linoleic acid level remained nearly constant. An increase in the palmitic acid and palmitoleic acid content of all the liver lipids analyzed was observed and was attributed to the high carbohydrate content of the semi-purified diets. It was concluded that the accumulation of liver neutral lipid during choline deficiency in the rat is not accompanied by changes in the fatty acid patterns of liver neutral lipids or liver phospholipids which can be ascribed directly to the lack of choline. The alterations noted in the liver lipid fatty compositions may be attributed to changes in the dietary fat and to the dietary carbohydrate levels.