POLYMERIC PHOSPHONIUM SALTS AS A NOVEL CLASS OF CATIONIC BIOCIDES .2. EFFECTS OF COUTER ANION AND MOLECULAR-WEIGHT ON ANTIBACTERIAL ACTIVITY OF POLYMERIC PHOSPHONIUM SALTS
POLYMERIC PHOSPHONIUM SALTS AS A NOVEL CLASS OF CATIONIC BIOCIDES .2. EFFECTS OF COUTER ANION AND MOLECULAR-WEIGHT ON ANTIBACTERIAL ACTIVITY OF POLYMERIC PHOSPHONIUM SALTS
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DOI：
10.1002/pola.1993.080310611
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发表时间：
1993-05-01
影响因子：
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通讯作者：
ENDO, T
中科院分区：
文献类型：
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作者：
KANAZAWA, A;IKEDA, T;ENDO, T
制备了不同抗衡阴离子的聚[三丁基（4-乙烯基苄基）鏻盐]，采用活菌计数法研究了其在无菌蒸馏水中对金黄色葡萄球菌的抗菌活性。抗菌活性被认为是由抗衡阴离子的结构的影响。对于倾向于与鳞离子形成紧密离子对的抗衡阴离子，活性较低，而对于促进离子解离成游离离子的抗衡阴离子，活性较高。此外，研究了不同分子量的聚[三丁基（4-乙烯基苄基）氯化鏻]对S.金黄色。发现抗菌活性随着分子量的增加而增加。通过改变三丁基（4-乙烯基苄基）氯化鏻与丙烯酰胺、N-乙烯基-2-吡咯烷酮或苯乙烯的组成比，制备了不同的共聚物，并研究了正电荷密度对共聚物抗菌活性的影响。金黄色。共聚物的抗菌活性远高于低分子量模型化合物的抗菌活性，并且随着共聚物中磷单元的摩尔分数的增加而增强。
Various poly[tributyl(4-vinylbenzyl)phosphonium salt]s with different counter anions were prepared and their antibacterial activities against Staphylococcus aureus were explored by the viable cell counting method in sterile distilled water. Antibacterial activity was found to be affected by the structure of the counter anions. The activity was low for a counter anion which tends to form a tight ion-pair with phosphonium ion, while it was high for those facilitating ionic dissociation to free ions. Furthermore, the molecular weight dependence of the antibacterial activity was investigated for poly[tributyl(4-vinylbenzyl) phosphonium chloride] with various molecular weights against S. aureus. Antibacterial activity was found to increase with molecular weight. Various copolymers were prepared in which the compositional ratio of tributyl (4-vinylbenzyl) phosphonium chloride to acrylamide, N-vinyl-2-pyrrolidone, or styrene was altered, and the effect of the positive charge density on the antibacterial activity was investigated against S. aureus. Antibacterial activity of the copolymers was much higher than that of the low-molecular-weight model compound and enhanced with the molar fraction of the phosphonium units in the copolymers.