Clinical neuroprediction: Amygdala reactivity predicts depressive symptoms 2 years later
Clinical neuroprediction: Amygdala reactivity predicts depressive symptoms 2 years later
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DOI：
10.1093/scan/nsw018
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发表时间：
2016-06-01
影响因子：
4.2
通讯作者：
Monk, Christopher S.
中科院分区：
文献类型：
--
作者：
Mattson, Whitney I.;Hyde, Luke W.;Monk, Christopher S.
抑郁症与杏仁核对中性和负价面部表情的激活增加有关。杏仁核激活可能预示抑郁症状随时间的变化。然而，这一领域的大多数研究都集中在小的，主要是女性和同质的临床样本。需要研究杏仁核反应性如何与抑郁症状的过程维度，前瞻性和不同性别，种族和社会经济地位的人群。共有156名来自低收入背景的男性完成了一项功能磁共振成像任务，他们观察了情绪化的面部表情。左、右杏仁核对中性但不愤怒或恐惧的面部表情的反应相对于20岁时的非面部基线预测了2年后更严重的抑郁症状，控制了20岁的抑郁症状。在一个大的社区样本中，双侧杏仁核对中性面部表情的反应性升高预测了2年后抑郁症状的增加。中性的面部表情在情感上是模糊的，对这些刺激进行负面解释的倾向可能反映出认知偏见，导致抑郁症状随着时间的推移而增加。杏仁核对中性面部表情反应的个体差异似乎可以识别出那些随着时间的推移更容易出现抑郁症状的人。
Depression is linked to increased amygdala activation to neutral and negatively valenced facial expressions. Amygdala activation may be predictive of changes in depressive symptoms over time. However, most studies in this area have focused on small, predominantly female and homogenous clinical samples. Studies are needed to examine how amygdala reactivity relates to the course of depressive symptoms dimensionally, prospectively and in populations diverse in gender, race and socioeconomic status. A total of 156 men from predominately low-income backgrounds completed an fMRI task where they viewed emotional facial expressions. Left and right amygdala reactivity to neutral, but not angry or fearful, facial expressions relative to a non-face baseline at age 20 predicted greater depressive symptoms 2 years later, controlling for age 20 depressive symptoms. Heightened bilateral amygdala reactivity to neutral facial expressions predicted increases in depressive symptoms 2 years later in a large community sample. Neutral facial expressions are affectively ambiguous and a tendency to interpret these stimuli negatively may reflect to cognitive biases that lead to increases in depressive symptoms over time. Individual differences in amygdala reactivity to neutral facial expressions appear to identify those at most risk for a more problematic course of depressive symptoms across time.