Interictal plasma pituitary adenylate cyclase-activating polypeptide levels are decreased in migraineurs but remain unchanged in patients with tension-type headache
Interictal plasma pituitary adenylate cyclase-activating polypeptide levels are decreased in migraineurs but remain unchanged in patients with tension-type headache
复制标题
偏头痛患者发作间期血浆垂体腺苷酸环化酶激活多肽水平降低，但紧张型头痛患者保持不变。
DOI：
10.1016/j.cca.2015.08.017
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发表时间：
2015-10-23
影响因子：
5
通讯作者：
Yu, Shengyuan
中科院分区：
文献类型：
--
作者：
Han, Xun;Dong, Zhao;Yu, Shengyuan
背景资料：腺苷酸环化酶激活多肽（PACAP）与偏头痛相关联;然而，PACAP水平是否可用于区分偏头痛和紧张型头痛（TTH）仍然未知。我们比较了发作间期血浆PACAP水平之间的健康对照，偏头痛，TTH.Methods患者：发作间期血浆PACAP水平测定在133偏头痛，106例TTH患者，50名对照使用酶联免疫法。我们进一步评估了发作间期PACAP血浆浓度和临床参数之间的关系，如头痛的严重程度，发作频率，和duration.Results：我们发现，偏头痛患者发作间期血浆PACAP水平显着低于TTH患者和健康对照组。然而，TTH患者和健康对照组之间无显著差异。发作性偏头痛（EM）患者的血浆PACAP水平显著低于发作性紧张型头痛（ETTH）患者，慢性偏头痛（CM）患者的血浆PACAP水平显著低于慢性紧张型头痛（CTTH）患者。发作间期PACAP水平呈负相关，持续时间在CM group.Conclusions：本研究的结果表明，发作间期PACAP水平在偏头痛和TTH的差异，这表明PACAP参与偏头痛的发病机制，而不是TT-I。(C)2015 Elsevier B. V.版权所有。
Background: Pituitary adenylate cyclase-activating polypeptide (PACAP) is associated with migraine phase; however, whether PACAP levels could be used to distinguish between migraine and tension-type headache (TTH) remains unknown. We compared interictal plasma PACAP levels among healthy controls, migraineurs, and patients with TTH.Methods: Interictal plasma levels of PACAP were measured in 133 migraineurs, 106 patients with TTH, and 50 controls using enzyme-linked immunoassays. We further evaluated the relationships between interictal PACAP plasma concentrations and clinical parameters, such as headache severity, attack frequency, and duration.Results: We found that migraineurs had significantly lower interictal plasma PACAP levels than patients with TTH and healthy controls. However, there were no significant differences between patients with TTH and healthy controls. Plasma PACAP levels were significantly lower in patients with episodic migraine (EM) than in patients with episodic tension-type headache (ETTH) and in patients with chronic migraine (CM) than in patients with chronic tension-type headache (CTTH). Interictal PACAP levels were negatively correlated with duration in the CM group.Conclusions: The results of this study demonstrated differences in interictal PACAP levels in migraine and TTH, suggesting that PACAP is involved in the pathogenesis of migraine rather than TT-I. (C) 2015 Elsevier B.V. All rights reserved.