Monodisperse Hollow MnO2 with Biodegradability for Efficient Targeted Drug Delivery
Monodisperse Hollow MnO2 with Biodegradability for Efficient Targeted Drug Delivery
复制标题
具有生物降解性的单分散空心 MnO2 可实现高效靶向药物输送
DOI：
10.1021/acsbiomaterials.0c00507
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发表时间：
2020-09-01
影响因子：
5.8
通讯作者：
Yan, Wangjun
中科院分区：
文献类型：
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作者：
Cheng, Mo;Yu, Yan;Yan, Wangjun
开发具有理想降解性和靶向性的新型纳米载体对高效给药具有重要意义。本工作制备了具有介孔结构的单分散中空结构MnO2(H-MnO2)，并对其进行了功能化处理，实现了高效的靶向给药。通过在固体二氧化硅纳米颗粒上原位生长二氧化锰，然后去除硅核，得到了高度单分散、形貌均匀的H-MnO2。然后，用聚乙二醇靶向分子叶酸(FA)对H-MnO2进行连续修饰。所得H-MnO2-FA具有良好的胶体稳定性和抗肿瘤药物盐酸阿霉素的高载药量(类似于58.2%)。H-MnO2-FA具有酸响应的T-1加权磁共振成像能力。直接在体外观察H-MnO2-FA的pH依赖生物降解行为，并通过体内成像证实，这有望有利于这种中空结构的纳米载体的潜在清除，并消除其长期毒性。此外，负载DOX的H-MnO2-FA还表现出良好的肿瘤细胞杀伤效果和肿瘤抑制效果。
The development of new nanocarriers with desired degradability and targeted ability is of great significance for efficient drug delivery. In this work, a monodisperse hollow structured MnO2 (H-MnO2) with a mesoporous shell is prepared and functionalized for efficient targeted drug delivery. The highly monodisperse H-MnO2 with a uniform morphology was obtained by in situ growing MnO2 on solid silica nanoparticles and subsequently removing the silica core. Then, the H-MnO2 is successively modified with polyethylene glycol and targeted molecule folate (FA). The resultant H-MnO2-FA shows excellent colloidal stability and high drug-loading content (similar to 58.2%) of the antitumor drug doxorubicin hydrochloride (DOX). The H-MnO2-FA possesses acid-responsive T-1-weighted magnetic resonance imaging ability. The pH-dependent biodegradation behavior of H-MnO2-FA is directly observed in vitro and confirmed by in vivo imaging, which is expected to favor the potential clearance of this hollow structured nanocarrier and eliminate its long-term toxicity. In addition, the DOX-loaded H-MnO2-FA also demonstrates excellent cancer cell-killing effect and tumor inhibition efficacy.