A case of primary small cell carcinoma of the breast.
A case of primary small cell carcinoma of the breast.
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DOI：
10.2325/jbcs.14.414
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Takahashi, Yutaka
中科院分区：
文献类型：
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作者：
Kitakata, Hidekazu;Yasumoto, Kazuo;Takahashi, Yutaka
我们报告一个罕见的情况下，原发性小细胞癌的乳房。一位44岁的女性因左乳房肿块入院。细针穿刺活检发现小细胞癌与神经内分泌分化类似的小细胞肺癌。全身计算机断层扫描（CT）和磁共振成像（MRI）显示肺或任何其他器官中没有原发部位。行改良根治性乳房切除术，切除腋窝淋巴结（Bt + Ax，R2）。组织学检查显示肿瘤由小的圆形至椭圆形细胞组成，核质比大。肿瘤细胞的神经内分泌分化标志物，如突触素，CD 56和神经元特异性烯醇化酶（NSE）呈阳性，但甲状腺转录因子-1（TTF-1），白细胞共同抗原（LCA），雌激素受体（ER）和孕激素受体（PR）呈阴性。有趣的是，肿瘤细胞缺乏上皮标志物的免疫反应性，包括细胞角蛋白AE 1/3，CAM 5.2和上皮膜抗原（EMA）。患者因腋窝淋巴结转移接受辅助化疗。术后22个月无复发迹象。
We report a rare case of primary small cell carcinoma of the breast. A 44-year-old woman was admitted to our hospital with a mass in her left breast. Fine-needle biopsy revealed small cell carcinoma with neuroendocrine differentiation resembling small cell carcinoma of the lung. Systemic computed tomography (CT) and magnetic resonance imaging (MRI) revealed no primary site in the lung or any other organ. A modified radical mastectomy with removal of the axillary lymph node (Bt + Ax, R2) was performed. Histological examination revealed that the tumor was composed of small round to oval cells with a large nuclear-cytoplasmic ratio. The tumor cells were positive for neuroendocrine differentiation markers such as synaptophysin, CD56, and neuron-specific enolase (NSE), but negative for thyroid transcription factor-1 (TTF-1), leukocyte common antigen (LCA), estrogen receptor (ER), and progesterone receptor (PR). Interestingly, the tumor cells lacked immunoreactivity for epithelial markers, including cytokeratin AE1/3, CAM5.2, and epithelial membrane antigen (EMA). The patient was given adjuvant chemotherapy for axillary lymph node metastasis. There were no signs of recurrence 22 months after surgery.