Function and structure of inherently disordered proteins
Function and structure of inherently disordered proteins
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DOI：
10.1016/j.sbi.2008.10.002
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发表时间：
2008-12-01
影响因子：
6.8
通讯作者：
Sussman, Joel L.
中科院分区：
文献类型：
--
作者：
Dunker, A. Keith;Silman, Israel;Sussman, Joel L.
生物信息学方法对蛋白质本身缺乏三维结构的应用引起了人们对这些大分子的越来越多的关注。本文讨论了这些蛋白质的相关主题，包括它们的氨基酸序列预测、它们在真核生物中相对于原核生物的富集、它们相对于结构蛋白的更快进化、它们的组织结构、它们的结构偏好、它们在细胞中的半衰期、它们对信号多样性的贡献（通过高含量的多伴侣结合位点、翻译后修饰和选择性剪合）。与结构蛋白相比，它们具有独特的功能，并与疾病有关。
The application of bioinformatics methodologies to proteins inherently lacking 3D structure has brought increased attention to these macromolecules. Here topics concerning these proteins are discussed, including their prediction from amino acid sequence, their enrichment in eukaryotes compared to prokaryotes, their more rapid evolution compared to structured proteins, their organization into specific groups, their structural preferences, their half-lives in cells, their contributions to signaling diversity (via high contents of multiple-partner binding sites, post-translational modifications, and alternative splicing), their distinct functional repertoire compared to that of structured proteins, and their involvement in diseases.